Aubrey de Grey Concepts

To Be a Machine: Adventures Among Cyborgs, Utopians, Hackers, and the Futurists Solving the Modest Problem of Death

by Mark O'Connell · 28 Feb 2017 · 252pp · 79,452 words

goes into life extension research, and we actually achieve longevity escape velocity.” He was referring here to the scenario, projected by the life extension impresario Aubrey de Grey, a scientific advisor at Alcor, whereby for every year that passes, the progress of longevity research is such that average human life expectancy increases by

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.” Solve the brain. Solve death. Solve being alive. Among the life extension researchers who had received funding from Thiel was an English biomedical gerontologist named Aubrey de Grey. De Grey was the director of a nonprofit called SENS (Strategies for Engineered Negligible Senescence). He had attracted considerable notoriety for the claim that he

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winnable. (Although, as he put it to me, if he were in Page and Brin’s position, he’d “obviously have given the money to Aubrey de Grey.”) I left the bar. Out on Taylor Street, I glanced back through the window. Aubrey was still at the table, his laptop open now in

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to acknowledge, was not really a party in any meaningful sense anyway, so much as just him and a handful of advisors. (At that point, Aubrey de Grey was on board as the campaign’s “anti-aging advisor,” and Martine Rothblatt’s son Gabriel—who had himself run for Congress in 2014—was

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about living forever. Not, like, five hundred years like a lot of transhumanists. Forever.” Like many transhumanists, he was deeply convinced of the importance of Aubrey de Grey’s SENS project. Aubrey was, for Roen, a figure of near-messianic dimensions. Most of what little money Roen raised as a life extension advocate

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one form or another, by many of the transhumanists I had spoken to over the previous eighteen months—by Natasha Vita-More, for instance, by Aubrey de Grey, by Randal Koene. We drove through the emptiness. Don’t Mess with Texas. Ruptured armadillos, rotting in the desert heat. Stand with Israel. Zoltan swigged

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of the following people: Zoltan Istvan, Roen Horn, Max More, Natasha Vita-More, Anders Sandberg, Nick Bostrom, David Wood, Hank Pellissier, Maria Konovalenko, Laura Deming, Aubrey de Grey, Mike La Torra, Randal Koene, Todd Huffman, Miguel Nicolelis, Edward Boyden, Nate Soares, David Deutsch, Viktoriya Krakovna, Janos Kramar, Stuart Russell, Tim Cannon, Marlo Webber

Immortality, Inc.

by Chip Walter · 7 Jan 2020 · 232pp · 72,483 words

,116 had already signed on to join the current tenants at some future date, including people like Ray Kurzweil, PayPal co-founder Peter Thiel, biogerontologist Aubrey de Grey, nanotechnology pioneer Eric Drexler, and, of course, Ralph Merkle. The average age of the currently vitrified is 65. Hixon is also Alcor’s chief depositor

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had been aware, vaguely, of various efforts to extend life. He had heard of Ray Kurzweil’s prescriptions for radical life extension, had come across Aubrey de Grey’s work on abolishing aging here and there, and suspected the National Institute on Aging (NIA), Harvard, MIT, and other organizations of that ilk had

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Nicholas Jasper de Grey, and the world would soon hear of him. 13 | LIFE EVERLASTING It was 4 a.m. in Manhattan Beach, California, and Aubrey de Grey was knackered. Still, he couldn’t sleep, partly because his brain was stuck in the British time zone he had departed just yesterday, and partly

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insights, and reveal them to others within the biogerontological fold. He was pretty sure they would conclude he had lost every one of his marbles. * * * — AUBREY DE GREY was a piece of work. In the early 2000s, he seemed to have dropped out of the sky like some John the Baptist, reap-the

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MIT Technology Review, Jason Pontin, asked Venter if he would sit on a small scientific committee whose job would be to review papers that refuted Aubrey de Grey’s claims that aging could be cured. They were calling it the SENS Challenge. Technology Review was a magazine read regularly by the geekerati, so

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known about how to do it. Later—though Levinson would never say so outright—these views had to include the thinking of Ray Kurzweil and Aubrey de Grey—and, in December 2015, Harvard genetics professor George Church, who announced at an international summit in Washington, D.C., that he was confident he could

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made presentations to one another, debated and plotted approaches. They visited research centers throughout the country—all the usual suspects (and a few elsewhere, including Aubrey de Grey, who very much wanted to work with Calico). Then they came back and tore the prevailing wisdom apart some more. Aging was not only poorly

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by using a cancer drug to destroy senescent cells that formed in the joints of aging mice. The idea was that these cells—the kind Aubrey de Grey finds so captivating—increase inflammation in the body. If the drugs reduced senescent cells in painful joints, was it possible your average human would also

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’s first artificial life-form, Craig Venter hadn’t really given the problem of aging and death much specific attention outside his brief adventure with Aubrey de Grey. All of that changed, though, the day he got on the phone with Bob Hariri and Peter Diamandis in the fall of 2012, not long

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the board), Alkahest, ZeroCater, Stemcentrx, Nootrobox, and Bulletproof, all now existed on California’s corporate rolls. These also included Venter’s Human Longevity, Inc., and Aubrey de Grey’s SENS Research Foundation. Many of these were included in a New Yorker article published in April 2017 entitled, “Silicon Valley’s Quest to Live

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big breakthroughs. None of these ventures had the financing of Calico or HLI, although interest in them was growing. Some efforts had the support of Aubrey de Grey’s SENS Research Foundation, the Buck Institute, or the occasional angel investor like Amazon CEO Jeff Bezos or PayPal’s Peter Thiel. But these fell

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, and start-ups with names like Halcyon Molecular and Butterfly Sciences. Some analysts reckon the market for regenerative medicine will hit $20 billion by 2025. Aubrey de Grey was still funding multiple longevity research projects including one at the University of Arizona and another at Yale. His SENS Research Foundation was doing so

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those ventures emerged—whether or not anyone believes it—because decades earlier Ray Kurzweil began ardently plowing the longevity road, with some serious help from Aubrey de Grey. They were the catalysts that set the grand endeavor into motion and attracted billions of dollars to the immortality business. The first breakthroughs are already

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for the interviews needed to write this book. These include many hours of meetings, phone calls, and emails with Ray Kurzweil, Arthur Levinson, Craig Venter, Aubrey de Grey, Robert Hariri, as well as long sessions with Bill Maris, David Botstein, Hal Barron, Cynthia Kenyon, Daphne Koller, Amalio Telenti, Riccardo Sabatini, Ken Bloom, Brad

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, Alphabet, Inc. J. Craig Venter, Human Longevity, Inc./The J. Craig Venter Institute Robert Hariri, Human Longevity, Inc./Celularity Peter Diamandis, Human Longevity, Inc./Celularity Aubrey de Grey, SENS Research Foundation Bill Maris, Section Hal Barron, Calico Labs David Botstein, Calico Labs Cynthia Kenyon, Calico Labs Daphne Koller, Calico Labs Bob Cohen, Calico

100 Plus: How the Coming Age of Longevity Will Change Everything, From Careers and Relationships to Family And

by Sonia Arrison · 22 Aug 2011 · 381pp · 78,467 words

be killed with the flick of a molecular switch.”88 Synthetic biology has many implications, but for those concerned with extending human health span, Dr. Aubrey de Grey offers what he believes is a comprehensive road map to fighting aging. A computer scientist turned gerontologist, de Grey believes that there are seven different

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Per Capita and Changing Family Size Some futurists have implied that as people live longer, the rate of childlessness may increase. For instance, aging theorist Aubrey de Grey argues that “our presumption that there is this innate drive to have kids, quite often, may not be so strong as we may have been

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of people, ranging from those who are seen as either cutting edge or “fringe” to those who are more mainstream. One well-known maven is Aubrey de Grey, whom we learned a bit about in Chapter 2. A computer scientist turned gerontologist, de Grey describes himself as a “fighter at heart.” He battles

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, and the Genomics X PRIZE is contributing to achieving that goal. Just as maven Ray Kurzweil is teamed up with connector Peter Diamandis, until recently Aubrey de Grey was teamed up with entrepreneur David Gobel. After meeting de Grey online in 2000, Gobel was inspired to start a nonprofit to support life-extension

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Mprize. He founded the Aging Research Network, a Canadian charity that sponsors “research to reverse the diseases of aging,” and he joined the board of Aubrey de Grey’s new SENS Foundation. He also cofounded the LifeStar Institute, an organization dedicated to “highlighting the economic imperatives for the development of therapies for age

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-meets-science projects, such as Halcyon Molecular, which is competing in the gene sequencing space. On the nonprofit side, Thiel has donated significant amounts to Aubrey de Grey’s work at the Methuselah Foundation and SENS Foundation as well as to organizations like the Singularity Institute for Artificial Intelligence and Singularity University, among

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wet in the biology area, and this has even forced some mavens to rethink how they talk about the subject. Mike Kope, the CEO of Aubrey de Grey’s SENS Foundation, says that the organization’s message is now quite simple: “repair the damage, don’t chase the pathology.” 74 And although science

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-Switch Included,” Wired News, February 5, 2010, www.wired.com/dangerroom/2010/02/pentagon-looks-to-breed-immortal-synthetic-organisms-molecular-kill-switch-included/. 89 Aubrey de Grey with Michael Rae, Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime (New York: St. Martin’s Press, 2007). 90 Jason

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Economy (Paris: OECD, 2003). Birthrates are derived from UN data, Table, Total Fertility (children per women), http://data.un.org/Browse.aspx?d=POP. 75 Aubrey de Grey, “What Is Human Nature?” Big Think interview, December 17, 2007, http://bigthink.com/ideas/4432. 76 www.childfree.net/ (last accessed February 2, 2010). 77

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,” The Oprah Show, March 24, 2009, www.oprah.com/health/Life-Extension-Technology-and-Tissue-Regeneration. 8 Ibid. 9 Gladwell, The Tipping Point, 66. 10 Aubrey de Grey with Michael Rae, Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime (New York: St. Martin’s Press, 2007), 10. 11

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Mitochondrial Free Radical Theory of Aging (Austin, TX: Landes Bioscience, November 2003); Michael Finkel, “Life Begins at 140,” GQ, May 2010. 12 Interview with Aubrey de Grey, November 20, 2010. 13 Finkel, “Life Begins at 140.” 14 Ben Goertzel, “AI Against Aging: Accelerating the Quest for Longevity via Intelligent Software,” Biomind LLC,

The Science and Technology of Growing Young: An Insider's Guide to the Breakthroughs That Will Dramatically Extend Our Lifespan . . . And What You Can Do Right Now

by Sergey Young · 23 Aug 2021 · 326pp · 88,968 words

is!” —Peter Diamandis, founder of the XPRIZE Foundation “Amazing research and the most exciting breakthroughs in the field of biomedicine and gerontology. Highly recommended!” —Dr. Aubrey de Grey, Chief Science Officer of the SENS Research Foundation “Read this book now. Researchers now know why we get old and what to do about it

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“You can live long enough to live forever.” —Ray Kurzweil, Inventor and Futurist “The first person to live to 150 has already been born.” —Dr. Aubrey de Grey, Biogerontologist “Until death, it is all life.” —Miguel de Cervantes, Author, Don Quixote Picture yourself on the occasion of your two hundredth birthday. You wake

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mentally adept. If that sounds crazy, read on. Entrepreneur David Gobel, together with the father of biogerontology (and scientific advisor to my Longevity Vision Fund), Aubrey de Grey, are founders of the not-for-profit Methuselah Foundation, whose goal is to “make ninety the new fifty by 2030.” David and Aubrey came up

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fifty of the leading longevity pioneers of our time. I am talking about super-stars like Harvard professor Dr. David Sinclair; acclaimed longevity pioneer Dr. Aubrey de Grey; genius geneticists like George Church, PhD, who helped develop the first direct genomic sequencing method; Dr. Cynthia Kenyon, one of the world’s foremost authorities

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grow old. We grow old because we stop playing.” —George Bernard Shaw, Playwright “Aging is just like smoking—it’s really bad for you.” —Dr. Aubrey de Grey, Biogerontologist “How old are you?” It’s a question you have probably been asked for as long as you can remember. Your age was perhaps

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In his seminal publication The Biology of Senescence, Dr. Comfort referred to aging as simply “a decrease in viability and an increase in vulnerability.” Dr. Aubrey de Grey, cofounder of the SENS Research Foundation, and an advisor to my Longevity Vision Fund, views aging as simply “an accumulation of molecular damage.” Sporting long

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of some of the hallmarks with specific age-related diseases. They are also not the only popular method of identifying the base characteristics of aging (Aubrey de Grey offers seven causes of aging that overlap with the ten hallmarks significantly but offer a slightly different model). What the hallmarks do is provide a

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going to be much more effective to treat yourself before you get sick, and then the whole medical industry will just respond to that,” says Aubrey de Grey. “They will make the medicines that people want to pay for.” De Grey’s comment really strikes at the heart of this thing. If it

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least theoretically possible. But to cross over from “living longer” to “living forever,” we return to the longevity escape velocity model from David Gobel and Aubrey de Grey that we first visited in chapter one. If this concept was new to you then, my guess is that you found it to be a

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argue passionately that defeating aging is technically impossible (it isn’t) and that it would be disastrous anyway (it won’t). This viewpoint is what Aubrey de Grey calls the “pro-aging trance.” “People who are totally rational and open to discourse on any other matter approach the topic of defeating aging with

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the frameworks needed for inspiring and rewarding critical breakthroughs in the field of longevity. It is my belief that, along with Peter Diamandis, Ray Kurzweil, Aubrey de Grey, David Sinclair, Nir Barzilai, Cynthia Kenyon, Eric Verdin, George Church, Martine Rothblatt, and all the other brilliant longevity pioneers you have met in this book

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Ferrazzi, Ray Kurzweil, Tony Robbins—for inspiring the reincarnation of Sergey Young and for helping me craft my longevity moonshot. To Dave Asprey, Nir Barzilai, Aubrey de Grey, Vishen Lakhiani, Greg McKeown, Jamie Metzl, David Perlmutter, David Sinclair, and Alex Zhavoronkov—for your inspiration, mentorship, and friendship. To Rony Abovitz, Daniel Amen, Jeffrey

The Transhumanist Reader

by Max More and Natasha Vita-More · 4 Mar 2013 · 798pp · 240,182 words

, and Cognitive Extension (Oxford University Press, 2010); Natural Born Cyborgs: Minds, Technologies, and the Future of Human (2003); and Intelligence Mindware (Oxford University Press, 2000). Aubrey de Grey, PhD, is Chief Science Officer, Strategies for Engineered Negligible Senescence Foundation. He co-authored with Michael Rae Ending Aging: The Rejuvenation Breakthroughs that Could Reverse

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the promotion of nutritional supplements that can be bought online, to say nothing of the excellent agit-prop for ending aging supplied by the relentless Aubrey de Grey over the last few years. The single best warrant for such chatter has been the creation of laboratory animals with greatly extended lifespans. I was

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again. Among these are the overpopulation, resources, boredom, and meaninglessness arguments. The essays in Part V address varied aspects and implications of radically extended lifespans. Aubrey de Grey critically analyses pro-mortality arguments by leading critics Leon Kass and William Hurlbut. Despite disagreeing with Kass’s conclusion, de Grey has a degree of

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, and of synthetic, non-physical realities in which we and the resurrected dead may live. 21 The Curate’s Egg of Anti-Anti-Aging Bioethics Aubrey de Grey As a leader of the crusade to defeat aging, working to demonstrate both its feasibility and its desirability, I am often seen as an implacable

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earnest” with the working draft of the human genome (circa 2000). Greg Klerkx 2006: 63. 7 Max More, Natasha Vita-More, Nick Bostrom, J. Hughes, Aubrey de Grey, Martine Rothblatt, Ben Goertzel, Ray Kurzweil, to name a few, all of whom are contributors to this seminal volume. 8 Through his analysis of technological

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most recent version in this volume) as an alternative to the unbalanced strictures of the Precautionary Principle. Summit keynotes included, in alphabetical order: Ronald Bailey, Aubrey de Grey, Robert A. Freitas, Raymond Kurzweil, Marvin Minsky, Max More, Christine Peterson, Michael D. Shapiro, Lee Silver, Gregory Stock, Natasha Vita-More, Roy Walford, and Michael

The Singularity Is Near: When Humans Transcend Biology

by Ray Kurzweil · 14 Jul 2005 · 761pp · 231,902 words

aging process. Can We Really Live Forever? An energetic and insightful advocate of stopping the aging process by changing the information processes underlying biology is Aubrey de Grey, a scientist in the department of genetics at Cambridge University. De Grey uses the metaphor of maintaining a house. How long does a house last

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sex," nobody would have taken you seriously. Yet that's just what happened—barrier contraception was widely adopted [around the time that infant mortality dropped]. —AUBREY DE GREY, GERONTOLOGIST We have a duty to die. —DICK LAMM, FORMER GOVERNOR OF COLORADO Some of us think this is rather a pity. —BERTRAND RUSSEL, 1955

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(New York: Hyperion, 2002); Allen Kurzweil, A Case of Curiosities (New York: Harvest Books, 2001). Allen Kurzweil is my first cousin. 38. As quoted in Aubrey de Grey, "Engineering Negligible Senescence: Rational Design of Feasible, Comprehensive Rejuvenation Biotechnology," Kronos Institute Seminar Series, February 8, 2002. PowerPoint presentation available at http://www.gen.cam

An Optimist's Tour of the Future

by Mark Stevenson · 4 Dec 2010 · 379pp · 108,129 words

’ – the idea that man could remain essentially human but transcend what nature had given him. Skip forward seventy-seven years to 2004 and you get Aubrey de Grey, a biogerontologist who declares, ‘I think the first person to live to a thousand might be sixty already.’ I’m travelling to see Nick because

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up by the anti-ageing part of the transhumanist project, the MIT Technology Review offered a $10,000 prize to anyone who could demonstrate that Aubrey de Grey’s ideas and research were ‘unworthy of learned debate.’ Jason Pontin, the Technology Review editor had previously written a stinging profile of de Grey, characterising

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a whole. To their credit, most transhumanists accept that ending ageing (if it’s possible) won’t arrive without massive upheavals to society. The question Aubrey de Grey asks is, ‘[Do the risks] outweigh the downside of doing the opposite, namely leaving ageing as it is … condemning a hundred thousand people a day

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argument that’s that strong then just don’t waste my time.’ For transhumanists this is a moral argument. On the issue of over-population Aubrey de Grey has written, ‘Basically our options are extremely simple: either restrict the birth rate or raise the death rate,’ by which he means if we all

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human limitations. The first is an attack on the restrictions of our biology. If the transhumanists wanted a field marshal to lead this advance, then Aubrey de Grey would be the obvious candidate. He’s encouraging the scientific community to find solutions to ‘seven major types of molecular and cellular damage that eventually

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a step toward the posthuman condition. The transhumanists know this. The rules are changing. Medical science is sounding the death knell of the old game. Aubrey de Grey has said his work isn’t about keeping people alive longer per se but ‘to stop people getting sick.’ Radically longer lives are, he suggests

Ageless: The New Science of Getting Older Without Getting Old

by Andrew Steele · 24 Dec 2020 · 399pp · 118,576 words

treatments for ageing. The first, originally published in 2002 and boldly entitled ‘Strategies for Engineered Negligible Senescence’ (SENS for short), was devised by maverick biogerontologist Aubrey de Grey. In its current form, SENS identifies seven differences between old bodies and young which de Grey suggests are the fundamental causes of ageing. It’s

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all the mitochondrial genes to the nucleus to combat mutations in ageing, rather than just one which is causing a specific mitochondrial disease, came from Aubrey de Grey, who we met in Chapter 4 as the father of ‘Strategies for Engineered Negligible Senescence’, or SENS. Accordingly, it’s his SENS Research Foundation that

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on the website of de Grey’s SENS Research Foundation: Intro to SENS research (SENS Research Foundation) ageless.link/owtoc3 or in his 2008 book Aubrey de Grey and Michael Rae, Ending Aging: The Rejuvenation Breakthroughs That Could Reverse Human Aging in Our Lifetime (St Martin’s Griffin, 2008) ageless.link/yvitd6 … the

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-edge results of their own. Thanks to Nick Lane, Desmond Tobin, Jon Houseley, João Pedro de Magalhães, Adam Rolt, Melinda Duer, Graham Ruby, Mike Philpott, Aubrey de Grey, Linda Partridge, David Gems, Sebastian Aguiar, Jim Mellon, Judith Campisi, Wolf Reik and Anders Sandberg. Secondly, I would like to thank those who read and

Singularity Rising: Surviving and Thriving in a Smarter, Richer, and More Dangerous World

by James D. Miller · 14 Jun 2012 · 377pp · 97,144 words

. Miller provides exactly that, and I hope and expect that his book will greatly raise the quality of debate and research in this critical area.” —Aubrey de Grey, leading biomedical gerontologist; former AI researcher “How can we be intelligent about superintelligence? Its finessed agility steers its course through the terrain of analytics and

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—famed investor and Singularity writer; •Justin Rattner—Intel’s chief technology officer; •Eric Drexler—the father of nanotechnology; •Peter Norvig—Director of Research at Google; •Aubrey de Grey—leading longevity researcher; •Stephen Wolfram—developer of the computation platform Mathematica; and •Jaan Tallinn—founding engineer of Skype and self-made tech decamillionaire who donated

The Future Is Faster Than You Think: How Converging Technologies Are Transforming Business, Industries, and Our Lives

by Peter H. Diamandis and Steven Kotler · 28 Jan 2020 · 501pp · 114,888 words

extended our average age to forty-eight years by 1950, then to seventy-two years by 2014. But these days, Ray Kurzweil and longevity expert Aubrey de Grey have begun talking about “longevity escape velocity,” or the idea that soon, science will be able to extend our lives by a year for every

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this conversation between Peter and Ray where they discuss the concept of longevity escape velocity: https://www.youtube.com/watch?time_continue=2&v=SaOfLtoaKqw. Aubrey de Grey: Kira Peikoff, “Anti-Aging Pioneer Aubrey de Grey: ‘People in Middle Age Now Have a Fair Chance,’ ” Leapsmag, January 30, 2018. See: https://leapsmag.com/anti-aging-pioneer

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-aubrey-de-grey-people-middle-age-now-fair-chance/. The Anti-Aging Pharmacy Easter Island is remote: Joe Schwarz, “The Right Chemistry: Easter Island Might Just Hold the