bioinformatics

back to index

119 results

The Zero Marginal Cost Society: The Internet of Things, the Collaborative Commons, and the Eclipse of Capitalism

by Jeremy Rifkin  · 31 Mar 2014  · 565pp  · 151,129 words

experiment with a new way of storing data that could eventually drop the marginal cost to near zero. In January 2013 scientists at the European Bioinformatics Institute in Cambridge, England, announced a revolutionary new method of storing massive electronic data by embedding it in synthetic DNA. Two researchers, Nick Goldman and

code is high and the time it takes to decode information is substantial. Researchers, however, are reasonably confident that an exponential rate of change in bioinformatics will drive the marginal cost to near zero over the next several decades. A near zero marginal cost communication/energy infrastructure for the Collaborative Age

. The intensification of genetic-Commons advocacy comes at a time when new IT and computing technology is speeding up genetic research. The new field of bioinformatics has fundamentally altered the nature of biological research just as IT, computing, and Internet technology did in the fields of renewable-energy generation and 3D

, and agribusiness. While the dual movements shared common philosophical ground, they also began to share technological ground with the birth of the new field of bioinformatics. Researchers began using computing technology to decipher, download, catalog, store, and reconfigure genetic information, creating a new kind of genetic capital for the Bioindustrial Age

accomplish the task. Titans in the computer field like Bill Gates and Wall Street insiders like Michael Milken poured funds into the new field of bioinformatics in hopes of advancing the collaborative partnership of the information and Life Sciences. Computers are not only being used to decipher and store genetic information

other genomes, are the “common heritage” of evolution and therefore cannot be enclosed as private property.29 Boyle sensed that while the new field of “bioinformatics blurs the line between computer modeling and biological research,” it might be possible that open-source genomics could liberate biological research from narrow corporate interests

replacing human labor, 121, 129, 267 and social media, 199–200 UPS uses, 11–12 and Watson, 130 bike sharing, 227 biocapacity, 274–275, 286 bioinformatics, 86, 169–171, 182 biosphere lifestyle, 297–303 Biosphere Politics (Rifkin), 167 The Biotech Century (Rifkin), 170 bitcoin, 262 Bok, Bernhard, 215 Botsman, Rachel, 234

New World View (Rifkin), 100 environmentalist(s), 170–172, 187–188 Environmental Movement, 173, 182, 185 era of transparency, 75–77 Etsy, 91, 262 European Bioinformatics Institute, 86 European Commission, 11, 76–77 European enclosures, and birth of the market economy, 29–38 exponential curves, 79– 81 “extreme productivity,” 3, 70

Data Mining: Concepts and Techniques: Concepts and Techniques

by Jiawei Han, Micheline Kamber and Jian Pei  · 21 Jun 2011

abnormalities in their data. The list continues, with cybersecurity and computer network intrusion detection; monitoring of the energy consumption of household appliances; pattern analysis in bioinformatics and pharmaceutical data; financial and business intelligence data; spotting trends in blogs, Twitter, and many more. Storage is inexpensive and getting even less so, as

data and multimedia data (e.g., pictures and videos) on web pages, graph data like web graphs, and map data on some web sites. In bioinformatics, genomic sequences, biological networks, and 3-D spatial structures of genomes may coexist for certain biological objects. Mining multiple data sources of complex data often

. It is impossible to enumerate all applications where data mining plays a critical role. Presentations of data mining in knowledge-intensive application domains, such as bioinformatics and software engineering, require more in-depth treatment and are beyond the scope of this book. To demonstrate the importance of applications as a major

development contributes significantly to the success of data mining and its extensive applications. ■ Data mining has many successful applications, such as business intelligence, Web search, bioinformatics, health informatics, finance, digital libraries, and digital governments. ■ There are many challenging issues in data mining research. Areas include mining methodology, user interaction, efficiency and

)? 1.10 Outline the major research challenges of data mining in one specific application domain, such as stream/sensor data analysis, spatiotemporal data analysis, or bioinformatics. 1.10. Bibliographic Notes The book Knowledge Discovery in Databases, edited by Piatetsky-Shapiro and Frawley [P-SF91], is an early collection of research papers

: Exploring Hyperlinks, Contents, and Usage Data by Liu [Liu06]; Data Mining: Introductory and Advanced Topics by Dunham [Dun03]; and Data Mining: Multimedia, Soft Computing, and Bioinformatics by Mitra and Acharya [MA03]. There are also books that contain collections of papers or chapters on particular aspects of knowledge discovery—for example, Relational

a small number of rows (also called transactions or tuples, e.g., samples). This is useful in applications like the analysis of gene expressions in bioinformatics, for example, where we often need to analyze microarray data that contain a large number of genes (e.g., 10,000 to 100,000) but

mining frequent patterns in various situations, many applications have hidden patterns that are tough to mine, due mainly to their immense length or size. Consider bioinformatics, for example, where a common activity is DNA or microarray data analysis. This involves mapping and analyzing very long DNA and protein sequences. Researchers are

[LHC97]; Silberschatz and Tuzhilin [ST96]; and Srikant, Vu, and Agrawal [SVA97]. Traditional pattern mining methods encounter challenges when mining high-dimensional patterns, with applications like bioinformatics. Pan, Cong, Tung, et al. [PCT+03] proposed CARPENTER, a method for finding closed patterns in high-dimensional biological data sets, which integrates the advantages

multiple genes, or cluster genes into groups. For example, we may find a group of genes that express themselves similarly, which is highly interesting in bioinformatics, such as in finding pathways. ■ When analyzing in the sample/condition dimension, we treat each sample/condition as an object and treat the genes as

may find the differences in gene expression by comparing a group of tumor samples and nontumor samples. Gene expression Gene expression matrices are popular in bioinformatics research and development. For example, an important task is to classify a new gene using the expression data of the gene and that of other

gene can participate in multiple clusters) nor exhaustive (e.g., where a gene may not participate in any cluster). Biclustering is useful not only in bioinformatics, but also in other applications as well. Consider recommender systems as an example. Using biclustering for a recommender system AllElectronics collects data from customers' evaluations

and social developments. Because biological sequences carry very complicated semantic meaning and pose many challenging research issues, most investigations are conducted in the field of bioinformatics. Sequential pattern mining has focused extensively on mining symbolic sequences. A sequential pattern is a frequent subsequence existing in a single sequence or a set

refer to sequences of nucleotides or amino acids. Biological sequence analysis compares, aligns, indexes, and analyzes biological sequences and thus plays a crucial role in bioinformatics and modern biology. Sequence alignment is based on the fact that all living organisms are related by evolution. This implies that the nucleotide (DNA, RNA

than sets, sequences, lattices, and trees. There is a broad range of graph applications on the Web and in social networks, information networks, biological networks, bioinformatics, chemical informatics, computer vision, and multimedia and text retrieval. Hence, graph and network mining have become increasingly important and heavily researched. We overview the following

proteomic data). Robust and dedicated analysis methods are needed for handling spatiotemporal data, biological data, related concept hierarchies, and complex semantic relationships. For example, in bioinformatics, a research problem is to identify regulatory influences on genes. Gene regulation refers to how genes in a cell are switched on (or off) to

Meeting of the Association for Computational Linguistics and Int. Conf. Computational Linguistics (COLING-ACL’98) Montreal, Quebec, Canada. (Aug. 1998). [BB01] Baldi, P.; Brunak, S., Bioinformatics: The Machine Learning Approach. 2nd ed. (2001) MIT Press, Cambridge, MA . [BB02] Borgelt, C.; Berthold, M.R., Mining molecular fragments: Finding relevant substructures of molecules

.; Niblett, T., A further comparison of splitting rules for decision-tree induction, Machine Learning 8 (1992) 75–85. [BO04] Baxevanis, A.; Ouellette, B.F.F., Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. 3rd ed. (2004) John Wiley & Sons . [BP92] Bezdek, J.C.; Pal, S.K., Fuzzy Models

data mining: A report on the KDD-98 panel, SIGKDD Explorations 1 (1999) 6–8. [JP04] Jones, N.C.; Pevzner, P.A., An Introduction to Bioinformatics Algorithms. (2004) MIT Press, Cambridge, MA . [JSD+10] Ji, M.; Sun, Y.; Danilevsky, M.; Han, J.; Gao, J., Graph regularized transductive classification on heterogeneous information

, M., The Data Warehouse Toolkit: The Complete Guide to Dimensional Modeling. 2nd ed. (2002) John Wiley & Sons . [KR03] Krane, D.; Raymer, R., Fundamental Concepts of Bioinformatics. (2003) Benjamin Cummings . [Kre02] Krebs, V., Mapping networks of terrorist cells, Connections 24 (2002) 43–52; (Winter). [KRR+00] Kumar, R.; Raghavan, P.; Rajagopalan, S

. 2005 ACM SIGSOFT Symp. Foundations of Software Engineering (FSE’05) Lisbon, Portugal. (Sept. 2005). [MA03] Mitra, S.; Acharya, T., Data Mining: Multimedia, Soft Computing, and Bioinformatics. (2003) John Wiley & Sons . [MAE05] Metwally, A.; Agrawal, D.; El Abbadi, A., Efficient computation of frequent and top-k elements in data streams, In: Proc

22 (1989) 2191–2204. [MO04] Madeira, S.C.; Oliveira, A.L., Biclustering algorithms for biological data analysis: A survey, IEEE/ACM Trans. Computational Biology and Bioinformatics 1 (1) (2004) 24–25. [MP69] Minsky, M.L.; Papert, S., Perceptrons: An Introduction to Computational Geometry. (1969) MIT Press, Cambridge, MA . [MRA95] Metha, M

Data Mining: Concepts, Models, Methods, and Algorithms

by Mehmed Kantardzić  · 2 Jan 2003  · 721pp  · 197,134 words

years, including causal feature selection and Relief. The book contains real-world case studies from a variety of areas, including text classification, web mining, and bioinformatics. Saul, L. K., et al., Spectral Methods for Dimensionality Reduction, in Semisupervised Learning, B. Schööelkopf, O. Chapelle and A. Zien eds., MIT Press, Cambridge, MA

mapping does not improve the SVM performance. Using the linear kernel is good enough, and C is the only tuning parameter. Many microarray data in bioinformatics and collection of electronic documents for classification are examples of this data set type. As the number of features is smaller, and the number of

. Other interesting application areas for SVMs are in text mining and categorization of large collection of documents, and in the analysis of genome sequences in bioinformatics. Furthermore, the SVM has been successfully used in a study of text and data for marketing applications. As kernel methods and maximum margin methods including

analyze past sales data to predict customer behavior, optimize robot behavior so that a task can be completed using minimum resources, and extract knowledge from bioinformatics data. Introduction to Machine Learning is a comprehensive textbook on the subject, covering a broad array of topics not usually included in introductory machine-learning

example, are patterns in a real-valued time series that may be of interest. Similarly, in symbolic sequences, regular expressions represent well-defined patterns. In bioinformatics, genes are known to appear as local patterns interspersed between chunks of noncoding DNA. Matching and discovery of such patterns are very useful in many

applications, not only in bioinformatics. Due to their readily interpretable structure, patterns play a particularly dominant role in data mining. There have been many techniques used to model global or

. It encompasses different forms of databases, including data warehouses, data cubes, tabular or relational data, and many applications, among which are music warehouses, video mining, bioinformatics, semantic Web and data streams. Li, H. X., V. C. Yen, Fuzzy Sets and Fuzzy Decision-Making, CRC Press, Inc., Boca Raton, 1995. The book

, New York, 1997. Thuraisingham, B., Data Mining: Technologies, Techniques, Tools, and Trends, CRC Press LLC, Boca Raton, FL, 1999. Tsur, S., Data Mining in the Bioinformatics Domain, Proceedings of the 26th YLDB Conference, Cairo, Egypt, 2000, pp. 711–714. Two Crows Corp., Introduction to Data Mining and Knowledge Discovery, Two Crows

. Wang, Y., F. Makedon, Application of Relief-F Feature Filtering Algorithm to Selecting Informative Genes for Cancer Classification Using Microarray Data, 2004 IEEE Computational Systems Bioinformatics Conference (CSB'04), Stanford, CA, August 2004. Weiss, S. M., N. Indurkhya, Predictive Data Mining: A Practical Guide, Morgan Kaufman Publishers, Inc., San Francisco, CA

Artificial Intelligence: A Modern Approach

by Stuart Russell and Peter Norvig  · 14 Jul 2019  · 2,466pp  · 668,761 words

et al., 2003), inferring cellular networks (Friedman, 2004), genetic linkage analysis to locate disease-related genes (Silberstein et al., 2013), and many other tasks in bioinformatics. We could go on, but instead we’ll refer you to Pourret et al. (2008), a 400-page guide to applications of Bayesian networks. Published

victory in the 2001 KDD Cup data mining competition for a Bayes net learning method (Cheng et al., 2002). (The specific task here was a bioinformatics problem with 139,351 features!) A structure-learning approach based on maximizing likelihood was developed by Cooper and Herskovits (1992) and improved by Heckerman et

et al., 2015) provides parse trees for a 3-million-word corpus of English. Many of the n-gram model techniques are also used in bioinformatics problems. Biostatistics and probabilistic NLP are coming closer together, as each deals with long, structured sequences chosen from an alphabet. Early part-of-speech (POS

., Li, P., Krishnan, A., and Liu, J. (2011). Large-scale dynamic gene regulatory network inference combining differential equation models with local dynamic Bayesian network analysis. Bioinformatics, 27 19, 2686–91. Liang, P., Jordan, M. I., and Klein, D. (2011). Learning dependency–based compositional semantics. arXiv:1109.6841. Liang, P. and Potts

, Z. U., Dechter, R., Thompson, E., and Geiger, D. (2013). A system for exact and approximate genetic linkage analysis of SNP data in large pedigrees. Bioinformatics, 29, 197–205. Silva, R., Melo, F. S., and Veloso, M. (2015). Towards table tennis with a quadrotor autonomous learning robot and onboard vision. In

., 515, 516, 799, 1087, 1111 binding list, 284 Bingham, E., 667, 1087 Binmore, K., 637, 1087 binocular stereopsis, 1009, 1009–1010, 1028 binomial nomenclature, 357 bioinformatics, 903 biological naturalism, 1036 Biran, O., 1060, 1088 Birattari, M., 160, 1093 Birbeck, M., 357, 1085 Bischof, J., 1060, 1087 Bishop, C. M., 160, 473

Forty Signs of Rain

by Kim Stanley Robinson  · 29 May 2004  · 362pp  · 104,308 words

of fields and really excellent in more than one. As good a scientist as one could find for the rather odd job of running the Bioinformatics Division at NSF, good almost to the point of exaggeration—too precise, too interrogatory—it kept her from pursuing a course of action with drive

worse.” They laughed. “And you have your journal work too.” “That’s right.” Frank waved at the piles of typescripts: three stacks for Review of Bioinformatics, two for The Journal of Sociobiology. “Always behind. Luckily the other editors are better at keeping up.” Anna nodded. Editing a journal was a privilege

credit hog, if not worse. It was interesting, then, that Pierzinski had gone down to Torrey Pines to work on a temporary contract, for a bioinformatics researcher whom Frank didn’t know. Perhaps that had been a bid to escape the advisor. But now he was back. Frank dug into the

, and kept her on the editorial board of The Journal of Statistical Biology, despite the fact that her job at NSF as director of the Bioinformatics Division might be said to be occupying her more than full-time already; but much of that job was administrative, and like the milk pumping

saps. Inch along. It stayed so bad that Frank realized he was going to be late to work. And this was the morning when his bioinformatics panel was to begin! He needed to get there for the panel to start on time; there was no slack in the schedule. The panel

eight of them sitting around the long cluttered conference table. Dr. Frank Vanderwal, moderator, NSF (on leave from University of California, San Diego, Department of Bioinformatics). Dr. Nigel Pritchard, Georgia Institute of Technology, Computer Sciences. Dr. Alice Freundlich, Harvard University, Department of Biochemistry. Dr. Habib Ndina, University of Virginia Medical School

. Some of the proposals brought up interesting problems, and several strong ones in a row made them aware of just how amazing contemporary work in bioinformatics was, and what some of the potential benefits for human health might be, if all this were to come together and make a robust biotechnology

board with that very same quick satisfied look. Now, in this room, Diane was already on to the next item on her agenda. AFTERWARD, THE bioinformatics group sat in Anna’s and Frank’s rooms on the sixth floor, sipping cold coffee and looking into the atrium. Edgardo came in. “So

Food Allergy: Adverse Reactions to Foods and Food Additives

by Dean D. Metcalfe  · 15 Dec 2008  · 623pp  · 448,848 words

chapter. Food allergen protein families Based on their shared amino acid sequences and conserved three-dimensional structures, proteins can be classified into families using various bioinformatics tools which form the basis of several protein family databases, one of which is Pfam [8]. Over the past 10 years or so there has

been an explosion in the numbers of well characterized allergens, which have been sequenced and are being collected into a number of databases to facilitate bioinformatic analysis [9]. We have undertaken this analysis for both plant [1] and animal food allergens [10] along with pollen allergens [2]. They show similar distributions

high identity of the molecular surfaces that are accessible to IgE and thus offer a molecular explanation for the observed clinical cross-reactivities. A structural bioinformatic analysis of Bet v 1 and its homologous allergens from apple, soybean, and celery showed that conservation of three-dimensional structure plays an important role

amino acid sequence to those of known allergens and gliadins as one of many assessments performed to evaluate product safety [4,69]. The purpose of bioinformatic analyses is to describe the biological and taxonomical relatedness of a query sequence to other functionally related proteins. In the context of allergy, the goal

at least 70% identity. Recent published work has led to the harmonization of the methods used for bioinformatic searches and a better understanding of the data generated [73,74] from such studies. An additional bioinformatics approach can be taken by searching for 100% identity matches along short sequences contained in the query

is normally present in food for human consumption derived from plant and microbial sources indicating that the protein has a long history of safe use. Bioinformatic analysis of CP4 EPSPS: A search for amino acid sequence similarity between the CP4 EPSPS protein and known allergens was conducted according to the methods

Clin Immunol 2000;106:228–38. 73 Thomas K, Bannon G, Hefle S, et al. In silico methods for evaluating human allergenicity to novel proteins. Bioinformatics Workshop Meeting Report, February 23–24, 2005. Toxicol Sci 2005;88:307–10. 74 Ladics GS, Bannon GA, Silvanovich A, Cressman, RF. Comparison of conventional

. 75 Bannon G, Ogawa T. Evaluation of available IgE-binding epitope data and its utility in bioinformatics. Mol Nutr Food Res 2006;50:638–44. 76 Hileman RE, Silvanovich A, Goodman RE, et al. Bioinformatic methods for allergenicity assessment using a comprehensive allergen database. Int Archives Allergy Immunol 2002;128:280–91

Beautiful Data: The Stories Behind Elegant Data Solutions

by Toby Segaran and Jeff Hammerbacher  · 1 Jul 2009

students in many scientific domains are playing the role of the Data Scientist. One of our hires for the Facebook Data team came from a bioinformatics lab where he was building data pipelines and performing offline data analysis of a similar kind. The well-known Large Hadron Collider at CERN generates

the most inefficient home-brewed language. However, the process of determining the exact order of these 3 billion bases requires a significant effort spanning chemistry, bioinformatics, laboratory procedures, and a lot of spinning disks. The Human Genome Project aimed, for the first time, to sequence every one of these characters. A

the sequencing data is available, it is stored in two formats in a high-performance Oracle database. While production systems make good use of databases, bioinformatics tools tend to continue to work against flat files on a physical filesystem. To be sure that we cater to all tastes, the vast swaths

the wider data web via RDF. RON is http://rdf.openmolecules. net, the resource that connects records from DBPedia, Chemical Blogspace, and ChEBI (a European Bioinformatics Institute Chemistry resource). Taking this one step further, we can link our experimental data into a wider discussion on the Web by using RDF from

and metaphysical naturalism. Pierre Lindenbaum obtained his PhD in virology in 2000, when he studied the virushost interactions. He then switched his professional career to bioinformatics, and after one year at the French National Center of Genotyping (France) he joined the French startup Integragen in 2001. He now works as a

The Wealth of Networks: How Social Production Transforms Markets and Freedom

by Yochai Benkler  · 14 May 2006  · 678pp  · 216,204 words

computational analysis, more can be organized for peer production. The relevant model here is open bioinformatics. Bioinformatics generally is the practice of pursuing solutions to biological questions using mathematics and information technology. Open bioinformatics is a movement within bioinformatics aimed at developing the tools in an open-source model, and in providing access to

the tools and the outputs on a free and open basis. Projects like these include the Ensmbl Genome Browser, operated by the European Bioinformatics Institute and the Sanger Centre, or the National Center for Biotechnology Information (NCBI), both of which use computer databases to provide access to data and

The Architecture of Open Source Applications

by Amy Brown and Greg Wilson  · 24 May 2011  · 834pp  · 180,700 words

has two children and a very old cat. C. Titus Brown (Continuous Integration): Titus has worked in evolutionary modeling, physical meteorology, developmental biology, genomics, and bioinformatics. He is now an Assistant Professor at Michigan State University, where he has expanded his interests into several new areas, including reproducibility and maintainability of

Computer Science and Evolutionary Biology at Michigan State University. In her copious spare time, she likes to read, hike, travel, and hack on open source bioinformatics software. She blogs at http://www.voidptr.net. Francesco Cesarini (Riak): Francesco Cesarini has used Erlang on a daily basis since 1995, having worked in

is a contract software developer based in Dublin, Ireland. Currently he is working on tools for electronics design, though in a previous life he developed bioinformatics software. He has many audacious plans for Audacity, and he hopes some, at least, will see the light of day. Chris Davis (Graphite): Chris is

wild include the use of RCP to monitor the Mars Rover robots developed by NASA at the Jet Propulsion Laboratory, Bioclipse for data visualization of bioinformatics and Dutch Railway for monitoring train performance. The common thread that ran through many of these applications was that these teams decided that they could

precipitation values to a matplotlib function that generates a scatter plot. Most workflow systems are designed for a specific application area. For example, Taverna targets bioinformatics workflows, and NiPype allows the creation of neuroimaging workflows. While VisTrails supports much of the functionality provided by other workflow systems, it was designed to

In Our Own Image: Savior or Destroyer? The History and Future of Artificial Intelligence

by George Zarkadakis  · 7 Mar 2016  · 405pp  · 117,219 words

written on the DNA. Cutting-edge research in biology does not take place in vitro in a wet lab, but in silico in a computer. Bioinformatics – the accumulation, tagging, storing, manipulation and mining of digital biological data – is the present, and future, of biology research. The computer metaphor for life is

computers. Big data are our newfound economic bounty. The big data economy In 2010, I took a contract as External Relations Officer at the European Bioinformatics Institute (EBI) at Hinxton, Cambridge. The Institute is part of the intergovernmental European Molecular Biology Laboratory, and its core mission is to provide an infrastructure

placed on biological data. Almost everyone understood the potential for driving innovation through this data, and was ready to support the expansion of Europe’s bioinformatics infrastructure, even as Europe was going through the Great Recession. The message was simple and clear: whoever owned the data owned the future. Governments and

film), robot Andrew 55, 57 big bang of the modern mind 10, 12–15 big data economy 249–55 binary arithmetic 149 binary logic 198 bioinformatics 123, 249 Blade Runner (1982 film) 53–4, 57, 72 Bletchley Park codebreakers 234–6 body, role in consciousness 169–71 body–mind dualism 124

Fifty Degrees Below

by Kim Stanley Robinson  · 25 Oct 2005  · 560pp  · 158,238 words

The End of Medicine: How Silicon Valley (And Naked Mice) Will Reboot Your Doctor

by Andy Kessler  · 12 Oct 2009  · 361pp  · 86,921 words

Big Data Analytics: Turning Big Data Into Big Money

by Frank J. Ohlhorst  · 28 Nov 2012  · 133pp  · 42,254 words

The Singularity Is Near: When Humans Transcend Biology

by Ray Kurzweil  · 14 Jul 2005  · 761pp  · 231,902 words

Physics of the Future: How Science Will Shape Human Destiny and Our Daily Lives by the Year 2100

by Michio Kaku  · 15 Mar 2011  · 523pp  · 148,929 words

The Elements of Statistical Learning (Springer Series in Statistics)

by Trevor Hastie, Robert Tibshirani and Jerome Friedman  · 25 Aug 2009  · 764pp  · 261,694 words

100 Plus: How the Coming Age of Longevity Will Change Everything, From Careers and Relationships to Family And

by Sonia Arrison  · 22 Aug 2011  · 381pp  · 78,467 words

As the Future Catches You: How Genomics & Other Forces Are Changing Your Work, Health & Wealth

by Juan Enriquez  · 15 Feb 2001  · 239pp  · 45,926 words

Explaining Humans: What Science Can Teach Us About Life, Love and Relationships

by Camilla Pang  · 12 Mar 2020  · 256pp  · 67,563 words

Our Posthuman Future: Consequences of the Biotechnology Revolution

by Francis Fukuyama  · 1 Jan 2002  · 350pp  · 96,803 words

The Patient Will See You Now: The Future of Medicine Is in Your Hands

by Eric Topol  · 6 Jan 2015  · 588pp  · 131,025 words

Life at the Speed of Light: From the Double Helix to the Dawn of Digital Life

by J. Craig Venter  · 16 Oct 2013  · 285pp  · 78,180 words

Life's Greatest Secret: The Race to Crack the Genetic Code

by Matthew Cobb  · 6 Jul 2015  · 608pp  · 150,324 words

Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again

by Eric Topol  · 1 Jan 2019  · 424pp  · 114,905 words

Dinosaurs Rediscovered

by Michael J. Benton  · 14 Sep 2019

Essential Scrum: A Practical Guide to the Most Popular Agile Process

by Kenneth S. Rubin  · 19 Jul 2012  · 584pp  · 149,387 words

Protocol: how control exists after decentralization

by Alexander R. Galloway  · 1 Apr 2004  · 287pp  · 86,919 words

Pearls of Functional Algorithm Design

by Richard Bird  · 15 Sep 2010

The New Harvest: Agricultural Innovation in Africa

by Calestous Juma  · 27 May 2017

The Demon in the Machine: How Hidden Webs of Information Are Finally Solving the Mystery of Life

by Paul Davies  · 31 Jan 2019  · 253pp  · 83,473 words

Advances in Financial Machine Learning

by Marcos Lopez de Prado  · 2 Feb 2018  · 571pp  · 105,054 words

Reinventing Discovery: The New Era of Networked Science

by Michael Nielsen  · 2 Oct 2011  · 400pp  · 94,847 words

Exploring Everyday Things with R and Ruby

by Sau Sheong Chang  · 27 Jun 2012

Running Money

by Andy Kessler  · 4 Jun 2007  · 323pp  · 92,135 words

MacroWikinomics: Rebooting Business and the World

by Don Tapscott and Anthony D. Williams  · 28 Sep 2010  · 552pp  · 168,518 words

The Data Journalism Handbook

by Jonathan Gray, Lucy Chambers and Liliana Bounegru  · 9 May 2012

HBase: The Definitive Guide

by Lars George  · 29 Aug 2011

Algorithms Unlocked

by Thomas H. Cormen  · 15 Jan 2013

Mastering Structured Data on the Semantic Web: From HTML5 Microdata to Linked Open Data

by Leslie Sikos  · 10 Jul 2015

The Simulation Hypothesis

by Rizwan Virk  · 31 Mar 2019  · 315pp  · 89,861 words

The Science and Technology of Growing Young: An Insider's Guide to the Breakthroughs That Will Dramatically Extend Our Lifespan . . . And What You Can Do Right Now

by Sergey Young  · 23 Aug 2021  · 326pp  · 88,968 words

Walled Culture: How Big Content Uses Technology and the Law to Lock Down Culture and Keep Creators Poor

by Glyn Moody  · 26 Sep 2022  · 295pp  · 66,912 words

Human Diversity: The Biology of Gender, Race, and Class

by Charles Murray  · 28 Jan 2020  · 741pp  · 199,502 words

The Invisible Web: Uncovering Information Sources Search Engines Can't See

by Gary Price, Chris Sherman and Danny Sullivan  · 2 Jan 2003  · 481pp  · 121,669 words

The Mutant Project: Inside the Global Race to Genetically Modify Humans

by Eben Kirksey  · 10 Nov 2020  · 599pp  · 98,564 words

Solr 1.4 Enterprise Search Server

by David Smiley and Eric Pugh  · 15 Nov 2009  · 648pp  · 108,814 words

Exponential Organizations: Why New Organizations Are Ten Times Better, Faster, and Cheaper Than Yours (And What to Do About It)

by Salim Ismail and Yuri van Geest  · 17 Oct 2014  · 292pp  · 85,151 words

A Short History of Humanity: How Migration Made Us Who We Are

by Johannes Krause and Thomas Trappe  · 8 Apr 2021  · 218pp  · 62,621 words

The Coming Wave: Technology, Power, and the Twenty-First Century's Greatest Dilemma

by Mustafa Suleyman  · 4 Sep 2023  · 444pp  · 117,770 words

The Deep Learning Revolution (The MIT Press)

by Terrence J. Sejnowski  · 27 Sep 2018

Advances in Artificial General Intelligence: Concepts, Architectures and Algorithms: Proceedings of the Agi Workshop 2006

by Ben Goertzel and Pei Wang  · 1 Jan 2007  · 303pp  · 67,891 words

Boom: Bubbles and the End of Stagnation

by Byrne Hobart and Tobias Huber  · 29 Oct 2024  · 292pp  · 106,826 words

Succeeding With AI: How to Make AI Work for Your Business

by Veljko Krunic  · 29 Mar 2020

SQL Hacks

by Andrew Cumming and Gordon Russell  · 28 Nov 2006  · 696pp  · 111,976 words

Googled: The End of the World as We Know It

by Ken Auletta  · 1 Jan 2009  · 532pp  · 139,706 words

Natural language processing with Python

by Steven Bird, Ewan Klein and Edward Loper  · 15 Dec 2009  · 504pp  · 89,238 words

Inventors at Work: The Minds and Motivation Behind Modern Inventions

by Brett Stern  · 14 Oct 2012  · 486pp  · 132,784 words

Natural Language Annotation for Machine Learning

by James Pustejovsky and Amber Stubbs  · 14 Oct 2012  · 502pp  · 107,510 words

Tools for Computational Finance

by Rüdiger Seydel  · 2 Jan 2002  · 313pp  · 34,042 words

Golden Holocaust: Origins of the Cigarette Catastrophe and the Case for Abolition

by Robert N. Proctor  · 28 Feb 2012  · 1,199pp  · 332,563 words

Life on the Edge: The Coming of Age of Quantum Biology

by Johnjoe McFadden and Jim Al-Khalili  · 14 Oct 2014  · 476pp  · 120,892 words

The Master Algorithm: How the Quest for the Ultimate Learning Machine Will Remake Our World

by Pedro Domingos  · 21 Sep 2015  · 396pp  · 117,149 words

Machines of Loving Grace: The Quest for Common Ground Between Humans and Robots

by John Markoff  · 24 Aug 2015  · 413pp  · 119,587 words

Superintelligence: Paths, Dangers, Strategies

by Nick Bostrom  · 3 Jun 2014  · 574pp  · 164,509 words

Here Comes Everybody: The Power of Organizing Without Organizations

by Clay Shirky  · 28 Feb 2008  · 313pp  · 95,077 words

The Information: A History, a Theory, a Flood

by James Gleick  · 1 Mar 2011  · 855pp  · 178,507 words

Nexus

by Ramez Naam  · 16 Dec 2012  · 502pp  · 124,794 words

Scikit-Learn Cookbook

by Trent Hauck  · 3 Nov 2014

Origins: How Earth's History Shaped Human History

by Lewis Dartnell  · 13 May 2019  · 424pp  · 108,768 words

Robots Will Steal Your Job, But That's OK: How to Survive the Economic Collapse and Be Happy

by Pistono, Federico  · 14 Oct 2012  · 245pp  · 64,288 words

A Brief History of Everyone Who Ever Lived

by Adam Rutherford  · 7 Sep 2016

Ageless: The New Science of Getting Older Without Getting Old

by Andrew Steele  · 24 Dec 2020  · 399pp  · 118,576 words

The Pattern Seekers: How Autism Drives Human Invention

by Simon Baron-Cohen  · 14 Aug 2020

As Gods: A Moral History of the Genetic Age

by Matthew Cobb  · 15 Nov 2022  · 772pp  · 150,109 words

Upgrade

by Blake Crouch  · 6 Jul 2022  · 396pp  · 96,049 words

Spike: The Virus vs The People - The Inside Story

by Jeremy Farrar and Anjana Ahuja  · 15 Jan 2021  · 245pp  · 71,886 words

We Are Data: Algorithms and the Making of Our Digital Selves

by John Cheney-Lippold  · 1 May 2017  · 420pp  · 100,811 words

The Rust Programming Language, 2nd Edition

by Steve Klabnik and Carol Nichols  · 27 Feb 2023  · 648pp  · 183,275 words

The Equality Machine: Harnessing Digital Technology for a Brighter, More Inclusive Future

by Orly Lobel  · 17 Oct 2022  · 370pp  · 112,809 words

How to Spend a Trillion Dollars

by Rowan Hooper  · 15 Jan 2020  · 285pp  · 86,858 words

Text Analytics With Python: A Practical Real-World Approach to Gaining Actionable Insights From Your Data

by Dipanjan Sarkar  · 1 Dec 2016

The Quest: Energy, Security, and the Remaking of the Modern World

by Daniel Yergin  · 14 May 2011  · 1,373pp  · 300,577 words

Apache Solr 3 Enterprise Search Server

by Unknown  · 13 Jan 2012  · 470pp  · 109,589 words

Cooked: A Natural History of Transformation

by Michael Pollan  · 22 Apr 2013  · 476pp  · 148,895 words

Information: A Very Short Introduction

by Luciano Floridi  · 25 Feb 2010  · 137pp  · 36,231 words

The Industries of the Future

by Alec Ross  · 2 Feb 2016  · 364pp  · 99,897 words

Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing

by Kevin Davies  · 5 Oct 2020  · 741pp  · 164,057 words

Immortality, Inc.

by Chip Walter  · 7 Jan 2020  · 232pp  · 72,483 words

The Journey of Humanity: The Origins of Wealth and Inequality

by Oded Galor  · 22 Mar 2022  · 426pp  · 83,128 words

Coders at Work

by Peter Seibel  · 22 Jun 2009  · 1,201pp  · 233,519 words

Managing Projects With GNU Make

by Robert Mecklenburg and Andrew Oram  · 19 Nov 2004  · 471pp  · 94,519 words

ucd-csi-2011-02

by Unknown  · 1 Mar 2011

Gnuplot Cookbook

by Lee Phillips  · 15 Feb 2012  · 199pp  · 47,154 words

Business Metadata: Capturing Enterprise Knowledge

by William H. Inmon, Bonnie K. O'Neil and Lowell Fryman  · 15 Feb 2008  · 314pp  · 94,600 words

Hadoop: The Definitive Guide

by Tom White  · 29 May 2009  · 933pp  · 205,691 words

The Speed of Dark

by Elizabeth Moon  · 1 Jan 2002  · 445pp  · 129,068 words

The Future of the Brain: Essays by the World's Leading Neuroscientists

by Gary Marcus and Jeremy Freeman  · 1 Nov 2014  · 336pp  · 93,672 words

Complexity: A Guided Tour

by Melanie Mitchell  · 31 Mar 2009  · 524pp  · 120,182 words

From Counterculture to Cyberculture: Stewart Brand, the Whole Earth Network, and the Rise of Digital Utopianism

by Fred Turner  · 31 Aug 2006  · 339pp  · 57,031 words

The Theory That Would Not Die: How Bayes' Rule Cracked the Enigma Code, Hunted Down Russian Submarines, and Emerged Triumphant From Two Centuries of Controversy

by Sharon Bertsch McGrayne  · 16 May 2011  · 561pp  · 120,899 words

Data Science for Business: What You Need to Know About Data Mining and Data-Analytic Thinking

by Foster Provost and Tom Fawcett  · 30 Jun 2013  · 660pp  · 141,595 words

The Transhumanist Reader

by Max More and Natasha Vita-More  · 4 Mar 2013  · 798pp  · 240,182 words

We-Think: Mass Innovation, Not Mass Production

by Charles Leadbeater  · 9 Dec 2010  · 313pp  · 84,312 words

Big Data at Work: Dispelling the Myths, Uncovering the Opportunities

by Thomas H. Davenport  · 4 Feb 2014

The Half-Life of Facts: Why Everything We Know Has an Expiration Date

by Samuel Arbesman  · 31 Aug 2012  · 284pp  · 79,265 words

The Stack: On Software and Sovereignty

by Benjamin H. Bratton  · 19 Feb 2016  · 903pp  · 235,753 words

Age of Discovery: Navigating the Risks and Rewards of Our New Renaissance

by Ian Goldin and Chris Kutarna  · 23 May 2016  · 437pp  · 113,173 words

Bad Blood: Secrets and Lies in a Silicon Valley Startup

by John Carreyrou  · 20 May 2018  · 359pp  · 110,488 words

The Art of UNIX Programming

by Eric S. Raymond  · 22 Sep 2003  · 612pp  · 187,431 words

Doing Data Science: Straight Talk From the Frontline

by Cathy O'Neil and Rachel Schutt  · 8 Oct 2013  · 523pp  · 112,185 words

The Rise of Yeast: How the Sugar Fungus Shaped Civilisation

by Nicholas P. Money  · 22 Feb 2018

The Big Nine: How the Tech Titans and Their Thinking Machines Could Warp Humanity

by Amy Webb  · 5 Mar 2019  · 340pp  · 97,723 words

The Rust Programming Language

by Steve Klabnik and Carol Nichols  · 14 Jun 2018  · 821pp  · 178,631 words

Programming Rust: Fast, Safe Systems Development

by Jim Blandy and Jason Orendorff  · 21 Nov 2017  · 1,331pp  · 183,137 words

The Willpower Instinct: How Self-Control Works, Why It Matters, and What You Can Doto Get More of It

by Kelly McGonigal  · 1 Dec 2011  · 354pp  · 91,875 words

Data-Ism: The Revolution Transforming Decision Making, Consumer Behavior, and Almost Everything Else

by Steve Lohr  · 10 Mar 2015  · 239pp  · 70,206 words

Blockchain: Blueprint for a New Economy

by Melanie Swan  · 22 Jan 2014  · 271pp  · 52,814 words

Richard Dawkins: How a Scientist Changed the Way We Think

by Alan Grafen; Mark Ridley  · 1 Jan 2006  · 286pp  · 90,530 words

RDF Database Systems: Triples Storage and SPARQL Query Processing

by Olivier Cure and Guillaume Blin  · 10 Dec 2014