description: scientific and medical research aimed at extending the human lifespan
155 results
by Jacob Silverman · 9 Oct 2025 · 312pp · 103,645 words
Roman dictator to cleanse, perhaps literally, the body politic. Playing the role of market fundamentalists, these tech titans preached crypto, artificial intelligence, space travel, and life extension while most people just wanted messaging apps, free healthcare, and affordable housing. Once, they aspired to solving real material problems; now, they seemed more concerned
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-state by creating autonomous corporatist nations, either on the open sea or on land carved off from countries with weak governments. He put millions into life extension research and said that he wanted to overcome death itself. Since his PayPal days, Thiel had talked about his belief that companies and individuals could
by Takuro Sato · 17 Nov 2015
would have a bit longer term. Upon fulfilling the debt service, the only remaining costs are of Operation and Maintenance (O&M), and of the life extension of the equipment and structures. Once the debt is repaid the cost of power is reduced significantly. For example, the cost of power drops to
by Joe Aston · 27 Oct 2024 · 362pp · 130,141 words
by 2024, you could almost accept Qantas’ rationale. But for Qantas’ other aircraft, it was a piss-take. How do you give a six-year life extension to an aircraft because it’s flown ten months fewer? All of these choices in fleet investment were how Qantas ended up with a passenger
by Ray Kurzweil · 14 Jul 2005 · 761pp · 231,902 words
will result from a single trend in to day's world as if nothing else will change. A good example is the concern that radical life extension will result in overpopulation and the exhaustion of limited material resources to sustain human life, which ignores comparably radical wealth creation from nanotechnology and strong
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underlying life, we are starting to learn to reprogram our biology to achieve the virtual elimination of disease, dramatic expansion of human potential, and radical life extension. Hans Moravec points out, however, that no matter how successfully we fine-tune our DNA-based biology, humans will remain "second-class robots," meaning that
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: Live Long Enough to Live Forever, which I coauthored with Terry Grossman, M.D., a leading longevity expert, we discuss these three bridges to radical life extension (today's knowledge, biotechnology, and nanotechnology).12 I wrote there: "Whereas some of my contemporaries may be satisfied to embrace aging gracefully as part of
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be pieced together."19 De Grey believes we'll demonstrate "robustly rejuvenated" mice—mice that are functionally younger than before being treated and with the life extension to prove it—within ten years, and he points out that this achievement will have a dramatic effect on public opinion. Demonstrating that we can
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for the societal effects that proponents of this theory have claimed, so the hypothesis does not appreciably challenge the conclusion that genes that supported significant life extension were not selected for. Aging is not a single process but involves a multiplicity of changes. De Grey describes seven key aging processes that encourage
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. Evidence from the genome project indicates that no more than a few hundred genes are involved in the aging process. By manipulating these genes, radical life extension has already been achieved in simpler animals. For example, by modifying genes in the C. elegans worm that control its insulin and sex-hormone levels
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involves harnessing biology's own reproductive mechanisms in the form of cloning. Cloning will be a key technology—not for cloning actual humans but for life-extension purposes, in the form of "therapeutic cloning." This process creates new tissues with "young" telomere-extended and DNA-corrected cells to replace without surgery defective
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to confront and resolve each such problem . ·We can apply the enormous leverage provided by the acceleration of technology. A notable example is achieving radical life extension through "a bridge to a bridge to a bridge" (applying today's knowledge as a bridge to biotechnology, which in turn will bridge us to
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era of nanotechnology).4 This offers a way to live indefinitely now, even though we don't yet have all the knowledge necessary for radical life extension. In other words we don't have to solve every problem today. We can anticipate the capability of technologies that are coming—in five years
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—to another substrate. Although the new entity would act just like me, the question remains: is it really me? Some of the scenarios for radical life extension involve reengineering and rebuilding the systems and subsystems that our bodies and brains comprise. In taking part in this reconstruction, do I lose my self
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": opposition to any change in the nature of what it means to be human (for example, changing our genes and taking other steps toward radical life extension). This effort, too, will ultimately fail, however, because the demand for therapies that can overcome the suffering, disease, and short lifespans inherent in our version
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the American Chemical Society 123.9 (2001): 2058–59. 148. Robert A. Freitas, Jr. "Death Is an Outrage!" presented at the Fifth AlcorConference on Extreme Life Extension, Newport Beach, California, November 16, 2002, http://www.rfreitas.com/Nano/DeathIsAnOutrage.htm. 149. For example, the fifth annual BIOMEMS conference, June 2003, San Jose
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://www.gen.cam.ac.uk/sens/sensov.ppt. 39. Robert A. Freitas Jr., "Death Is an Outrage!" presentation at the fifth Alcor Conference on Extreme Life Extension, Newport Beach, Calif., November 16, 2002, http://www.rfreitas.com/Nano/DeathIsAnOutrage.htm, published on KurzweilAI.net January 9, 2003: http://www.KurzweilAI.net/articles
by Salim Ismail and Yuri van Geest · 17 Oct 2014 · 292pp · 85,151 words
further than anyone ever imagined. Google[X] offers two fascinating new extensions to the traditional approach. First, it aims for moonshot-quality ideas (e.g., life extension, autonomous vehicles, Google Glass, smart contact lenses, Project Loon, etc.). Second, unlike traditional corporate labs that focus on existing markets, Google[X] combines breakthrough technologies
by Francis Fukuyama · 29 Sep 2014 · 828pp · 232,188 words
Society (New York: Free Press, 1995). 14. See Fukuyama, Origins of Political Order, pp. 460–68. 15. I discuss the social and political consequences of life extension in Our Posthuman Future: Consequences of the Biotechnology Revolution (New York: Farrar, Straus and Giroux, 2002), pp. 57–71. 16. Karl Polanyi, The Great Transformation
by Dean D. Metcalfe · 15 Dec 2008 · 623pp · 448,848 words
–30. 3 Babich H. Butylated hydroxytoluene (BHT): a review. Environ Res 1982;29:1–29. 4 Llaurado JP. The saga of BHT and BHA in life extension myths. J Amer Coll Nutr 1985;4:481–4. 5 Lauer BH, Kirkpatrick DC. Antioxidants: the Canadian perspective. Toxicol Ind Health 1993;9:373–82
by Timothy Ferriss · 1 Dec 2010 · 836pp · 158,284 words
years. One explanation researchers have proposed is that the regular ofuro, or hot bath at bedtime, increases melatonin release and is related to mechanisms for life extension. Paradoxically, according to one of the Stanford professors who taught the sleep biology class I took circa 2002, cold is a more effective signaler (aka
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-recipient of 1965 Nobel Prize in Physics Not life, but good life, is to be chiefly valued. —Socrates This will be the shortest chapter on life-extension ever written. Let it begin, as all good short chapters do, with a story of two monkeys: Canto and Owen. Housed at the University of
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who got water. As Edgar notes in King Lear, “Ripeness is all.” You don’t get to ripeness by eating apple peel for breakfast.… When life extension supplants life quality as a goal, you get the desolation of Canto the monkey. Living to 120 holds zero appeal for me. Canto looks like
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goal is to live as long as possible, there is a long list, an endless list, of things to avoid. The good news is that life-extension need not be complicated. For the gents, it may be as simple as blocking a few websites and curbing a little maleness. The pro-ejaculation
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most effective natural means of protecting against breast cancer” due to the hormone hCG. Should you therefore have children before age 20? I suggest that life-extension is not a good enough reason, particularly since another life is involved. This option is therefore omitted from our list. Separating the wheat from the
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is why I’ll use resveratrol short-term at higher doses for endurance while tracking blood markers, but I won’t use it indefinitely for life-extension. Telomerase activators like TA-65, another example, are purported to extend our chromosomal countdown clocks called “telomeres.” TA-65 can cost up to $15,000
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using. All of them are low-cost, low-tech, and low-risk. Most of them also provide athletic or body composition benefits, even if their life-extension effects are later debunked: 1. CYCLES OF 5–10 GRAMS OF CREATINE MONOHYDRATE (COST: $20/MONTH) Creatine monohydrate, popular among power athletes since its commercialization
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to ensure no kidney problems. Complications are rare, but an ounce of prevention is worth a pound of cure. Nowhere is this truer than in life- extension. 2. INTERMITTENT FASTING (IF) AND PROTEIN CYCLING (COST: FREE) What if poor, hungry Canto only needed to fast on occasion to extend his life? Constant
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, which typically appears starting in the third week and averages one pound of loss per week thereafter.3 Some research suggests IF confers the same life-extension benefits as caloric restriction only when calories are consumed during daylight hours. This would, if accurate, make the Fast-5 better for fat loss than
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Forever by Ray Kurzweil (www.fourhourbody.com/transcend) Kurzweil, called the “rightful heir to Thomas Edison” by Inc. magazine, proposes that those interested in “radical life extension” should make it their immediate goal to live through the next 20 or so years, in order to see advances like DNA reprogramming and submicroscopic
by Geoffrey West · 15 May 2017 · 578pp · 168,350 words
the problem of aging; and Larry Page, a cofounder of Google, who started Calico (the California Life Company), whose focus is on aging research and life extension. And then there’s the health care mogul Joon Yun, who, though he didn’t make his fortune in classic high-tech, is based in
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fewer than Sarah, while the oldest person still alive today is the Italian Emma Murano, who is “only” in her 118th year. The search for life extension can therefore be boiled down to two major categories: (1) The conservative challenge: how can the rest of us continue the upward march toward a
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Xiaoping, 389 determinate growth, 165–66 Detroit, 359 “developing” countries, 9, 185, 280 Dickens, Charles, 186, 223, 225, 226 diet caloric restriction, 205–7, 206 life extension and, 189 2,000 food calories a day, 13, 90, 234, 373 dimensionality of cities, 409 of companies, 409–10 dimensionless quantity, 76–77, 167
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, 192–94, 193 human survivorship curves, 189–94, 191, 192 maximum, 6, 24, 188–94, 202–3 temperature dependence of, 175, 176, 177, 203–4 life extension, 6, 183–94, 203–7 body temperature and, 203–4 caloric restriction and, 205–7, 206 heartbeats and pace of life, 204–5 Limehouse (London
by Jean-Marie Robine, James W. Vaupel, Bernard Jeune and Michel Allard · 2 Jan 1997
facultative male, which makes it extremely easy to identify mutations, even those that affect life span (Klass 1983; Duhon et al. 1996). For analysis of life extension and other life history traits, the lack of inbreeding depression is extremely important (Johnson and Wood 1982; Johnson and Hutchinson 1993). Moreover, because of its
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rate of mortality increase (Johnson 1990). Four other mutations lead to significant extension of adult life span in C. elegans. spe-26 mutants result in life extensions of about 65 % for the hermaphrodite and the mated male (Van Voorhies 1992; Murakami and Johnson 1996), although recent observations (Gems and Riddle 1996) suggest
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that the life extension may be artifactual and result from inappropriate comparisons with wild type. daf-2 mutants result in a more than Identifying and Cloning Longevity-Determining Genes
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, which have altered the normal course of the cell cycle and of development, also have a increased life span. The several unpublished cases of additional life-extension loci suggest that the total number of gerontogenes in C. elegans may be near 10. Physiological Role of These Gerontogenes All of the mutations mentioned
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. Tedesco and T. E. Johnson, unpublished. 16. S. Dale and T. E. Johnson, unpublished. 3 These genes showed allelic variation with only some alleles showing life extension; all life-extending alleles tested were also UV resistant. 4 Newly isolated mutants fail to complement age-I; other tests still pending. 40 65 100
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and Johnson 1996). In contrast to the many physiological mechanisms proposed initially, these findings suggest that a single pathway, involving daf-16, specifies both the life-extension and UVresistance phenotypes. The fact that mutations in daf-16 did not alter the reduced fertility of spe-26 (interestingly, a daf-16 mutant is
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) Genetic analysis of aging: Role of oxidative damage and environmental stresses. Nat Genetics 13:25-34 Murakami S, Johnson TE (1996) A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 143:1207-1218 Rattan SIS (1985) Beyond the present crisis in gerontology. Bioessays 2:226-228
by Ray Kurzweil · 25 Jun 2024
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