Ageless: The New Science of Getting Older Without Getting Old
by Andrew Steele · 24 Dec 2020 · 399pp · 118,576 words
, but staying younger for longer, with fewer and less severe age-related diseases. Rapamycin slows cell death and improves cognitive performance in the brains of mouse models* of Parkinson’s and Alzheimer’s, and improves the functioning of arteries in diabetic mice, probably by stimulating autophagy. This is an impressive proof of
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the 1990s). It’s hard to overemphasise how bizarre this is, but nonetheless GAIM has been shown to clear both amyloid beta and tau in mouse models of Alzheimer’s disease, and to improve their cognitive function. Human trials are ongoing, headed up by a company called Proclara Biosciences. Ideally, one or
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chemical secreted by the mould which was toxic to bacteria – eventually isolated and named penicillin after the Penicillium fungus in which it was discovered. *A ‘mouse model’ is what scientists call mice genetically modified to be at risk of a human disease, either because waiting around for them to get it would
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it’s often a vital first step in understanding how new treatments work. Nonetheless, bear in mind both in this book and elsewhere that a mouse model is one step further removed from the clinic than an experiment in normal mice might be. *Spermidine and related compound spermine were first observed by
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as SLAB51 was able to damp inflammation, reduce beta-amyloid and tau aggregation, reduce levels of advanced glycation end products and slow cognitive decline in mouse models of Alzheimer’s. Probiotics, prebiotics and synbiotics have also been successfully used in small human trials to improve symptoms in Alzheimer’s and control sugar
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risk of cancer in old mice, slow the progression of age-related heart problems, reduce the production of amyloid-beta and extend the lives of mouse models of Alzheimer’s, and improve muscle function in old mice. There are also several mitochondrially targeted antioxidant drugs in the works. Probably the most advanced
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found in our food, which has been shown to extend lifespan in worms, improve endurance and muscle strength in mice and slow cognitive decline in mouse models of Alzheimer’s, as well as improve mitochondrial function in people over 60. Other contenders for mitophagy-boosting include spermidine, one of the DR mimetics
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. There should be a similar refrain in geriatrics, that old people aren’t just old young people. The same problem plays out in mouse studies. ‘Mouse models’ of disease – which we’ve said before are often imperfect analogues – are particularly guilty in this regard. For example, a
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mouse model of Alzheimer’s might contain an extra copy of the amyloid precursor protein gene, and mice could develop amyloid deposits and cognitive impairment in mouse
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after your mice for a year or two while they grow old. However, it’s well known that lots of drugs which work flawlessly in mouse models fail to translate to human success. If your drug is for a disease primarily found in older patients, this is one of many possible reasons
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ageless.link/o44mop A probiotic cocktail … known as SLAB51 … Laura Bonfili et al., ‘Gut microbiota manipulation through probiotics oral administration restores glucose homeostasis in a mouse model of Alzheimer’s disease’, Neurobiol. Aging 87, 35–43 (2019). DOI: 10.1016/j.neurobiolaging.2019.11.004 ageless.link/jjwfum Probiotics, prebiotics and synbiotics
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/voxv4s … reduce the production of amyloid-beta … Peizhong Mao et al., ‘Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer’s disease: Implications for neuroprotection and lifespan extension’, Hum. Mol. Genet. 21, 2973–90 (2012). DOI: 10.1093/hmg/dds128 ageless.link/divufs
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microbiome, here, here heart rate, here and immune system therapies, here, here, here and longevity genes, here, here, here mitochondria, here and mitochondrial therapies, here mouse models, here and p53 gene, here and parabiosis, here, here, here and plasma transfusions, here and senescent cell research, here and stem cells, here, here, here
She Has Her Mother's Laugh
by Carl Zimmer · 29 May 2018
generation of graduate students silently thanked Jaenisch every day for making their lives easier. Many PhD projects had to start with the creation of a mouse model to study a gene or a disease. It typically took eighteen months to create a line of mice, and often it took more than one
The Emperor of All Maladies: A Biography of Cancer
by Siddhartha Mukherjee · 16 Nov 2010 · 1,294pp · 210,361 words
one, and three drugs better than two. With several drugs and several iterative rounds of chemotherapy in rapid-fire succession, Skipper cured leukemias in his mouse model. For Frei and Freireich, Skipper’s observations had an inevitable, if frightening, conclusion. If human leukemias were like Skipper’s mouse leukemias, then children would
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doctor” who had so deeply influenced Frei’s early work, to speak. Skipper was inching toward higher and higher doses of cytotoxic drugs in his mouse models and spoke enthusiastically about the possibility of curative treatment with these megadose regimens. He was soon after followed by Frank Schabel, another scientist who had
Texture: 20 Timeless Garments Exploring Knit, Yarn & Stitch
by Erika Knight · 21 Jan 2021 · 236pp · 50,215 words
erika knight gossypium cotton 100% cotton Approx. 100m (109yd) per 50g (1¾oz) ball NOTE Design shown in all photos is a size Medium. Colour: Mouse. Model: UK size 8. Height: 5’9½”. MATERIALS Quantity: 14(15:16:17) x 50g (1¾oz) balls 4.5mm needles 3.75mm circular needle—length
The Death of Cancer: After Fifty Years on the Front Lines of Medicine, a Pioneering Oncologist Reveals Why the War on Cancer Is Winnable--And How We Can Get There
by Vincent T. Devita, Jr., M. D. and Elizabeth Devita-Raeburn · 3 Nov 2015 · 386pp · 114,405 words
combination chemotherapy. Back on the boardwalk with, from left to right, Ron Yankee, who helped me decipher the cell growth rates of leukemia in our mouse model, which would help me transform MOMP into MOPP; George Canellos, nicknamer extraordinaire; and Jack Moxley Paul Carbone, chief of the NCI’s medicine branch at
Behave: The Biology of Humans at Our Best and Worst
by Robert M. Sapolsky · 1 May 2017 · 1,261pp · 294,715 words
previously, this produces persistent adverse consequences—a month later, such mice still had elevated glucocorticoid levels and were more anxious and more vulnerable to a mouse model of depression.* Importantly, the same persistent effects would be induced in a mouse merely observing another mouse experiencing that stressful intruder paradigm. An even more
The Cancer Chronicles: Unlocking Medicine's Deepest Mystery
by George Johnson · 26 Aug 2013 · 465pp · 103,303 words
so much like a tumor: The complex process of implantation is described in Haibin Wang and Sudhansu K. Dey, “Roadmap to Embryo Implantation: Clues from Mouse Models,” Nature Reviews Genetics 7, no. 3 (March 1, 2006): 185–99. [http://www.nature.com/nrg/journal/v7/n3/abs/nrg1808.html] For some of
CRISPR People: The Science and Ethics of Editing Humans
by Henry T. Greely · 22 Jan 2021
Johnston, “Embryology Policy: Revisit the 14-Day Rule,” Nature 533, no. 7602 (2016): 169–171, https://doi.org/10.1038/533169a. 14. Robert L. Perlman, “Mouse Models of Human Disease: An Evolutionary Perspective,” Evolution, Medicine, and Public Health 2016, no. 1 (January 2016), https://doi.org/10.1093/emph/eow014. 15. David
Lifespan: Why We Age—and Why We Don't Have To
by David A. Sinclair and Matthew D. Laplante · 9 Sep 2019
in Cell Biology 27, no. 9 (September 27, 2017): 685–96, https://www.ncbi.nlm.nih.gov/pubmed/28528987. 15. D. C. Dolinoy, “The Agouti Mouse Model: An Epigenetic Biosensor for Nutritional and Environmental Alterations on the Fetal Epigenome,” Nutrition Reviews 66, suppl. 1 (August 2008): S7–11, https://www.ncbi.nlm
The Gene: An Intimate History
by Siddhartha Mukherjee · 16 May 2016 · 824pp · 218,333 words
are the savants of the rodent world: Kiyohito Murai et al., “Nuclear receptor TLX stimulates hippocampal neurogenesis and enhances learning and memory in a transgenic mouse model,” Proceedings of the National Academy of Sciences 111, no. 25 (2014): 9115–20. “It may be the field’s dirty little secret”: Karen Hopkin, “Ready
Grain Brain: The Surprising Truth About Wheat, Carbs, and Sugar--Your Brain's Silent Killers
by David Perlmutter and Kristin Loberg · 17 Sep 2013
The Future of the Brain: Essays by the World's Leading Neuroscientists
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Potatoes not Prozac
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The Lucky Years: How to Thrive in the Brave New World of Health
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Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease and Inheritance
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Food Allergy: Adverse Reactions to Foods and Food Additives
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Sleepyhead: Narcolepsy, Neuroscience and the Search for a Good Night
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Junk DNA: A Journey Through the Dark Matter of the Genome
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A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution
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Editing Humanity: The CRISPR Revolution and the New Era of Genome Editing
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P53: The Gene That Cracked the Cancer Code
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Science Fictions: How Fraud, Bias, Negligence, and Hype Undermine the Search for Truth
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In Pursuit of Memory: The Fight Against Alzheimer's
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Immortality, Inc.
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The Fast Diet: Revised and Updated: Lose Weight, Stay Healthy, Live Longer
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The Science and Technology of Growing Young: An Insider's Guide to the Breakthroughs That Will Dramatically Extend Our Lifespan . . . And What You Can Do Right Now
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Deep Nutrition: Why Your Genes Need Traditional Food
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Exercised: The Science of Physical Activity, Rest and Health
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Inferior: How Science Got Women Wrong-And the New Research That's Rewriting the Story
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Practical Manual of Thyroid and Parathyroid Disease
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Hormone Repair Manual
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The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer
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Why We Sleep: Unlocking the Power of Sleep and Dreams
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The Singularity Is Near: When Humans Transcend Biology
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The Last Best Cure: My Quest to Awaken the Healing Parts of My Brain and Get Back My Body, My Joy, a Nd My Life
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Speculative Everything: Design, Fiction, and Social Dreaming
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Fiber Fueled: The Plant-Based Gut Health Program for Losing Weight, Restoring Your Health, and Optimizing Your Microbiome
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The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race
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The Autoimmune Connection
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Betrayal of Trust: The Collapse of Global Public Health
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Escape From Model Land: How Mathematical Models Can Lead Us Astray and What We Can Do About It
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Antifragile: Things That Gain From Disorder
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The Panic Virus: The True Story Behind the Vaccine-Autism Controversy
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Warnings
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Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity
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The Autistic Brain: Thinking Across the Spectrum
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Autism Adulthood: Strategies and Insights for a Fulfilling Life
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Life on the Rocks: Building a Future for Coral Reefs
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Space 2.0
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The Plague Year: America in the Time of Covid
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Against Technoableism: Rethinking Who Needs Improvement
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