randomized controlled trial
description: experimental method designed to reduce bias, typically accomplished by randomly allocating subjects to two or more groups, with one being a control group
302 results
The Hunger Code: How to Reset Your Body's Fat Thermostat by Breaking the Ultra-Processed Food Habit
by Jason Fung · 3 Mar 2026 · 284pp · 76,656 words
I showed in The Obesity Code, every scientific study proved it didn’t work. The Women’s Health Initiative observational study, one of the largest randomized controlled trials ever done, reduced participants’ caloric intake by 371 calories per day and increased their physical activity by 10 percent. Eat Less, Move More, right
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54 percent more weight than those taking the least.42 In the San Antonio Heart Study, weight gain was 78 percent higher.43 When all randomized controlled trials were reviewed, scientists concluded that “sweetener had no significant effect on BMI.”44 Yes, you could have a drink with zero calories, but no
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the cue with the many different motivations to eat (boredom, loneliness, food addictions, and so on), the urge to eat becomes irresistible. A two-year randomized controlled trial from Harvard University, published in 2017, confirmed that the more you eat certain foods, the more you will crave them, which supports the “conditioning
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.92. 10 Wexler DJ et al. Results of a 2-year lifestyle intervention for type 2 diabetes: the Reach Ahead for Lifestyle and Health-Diabetes randomized controlled trial. Obesity (Silver Spring). 2022 Aug 31;30(10):1938–50. doi: 10.1002/oby.23508. 11 Data source for Table 1.1: DeWolfe D
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-7. 27 Unhapipatpong C et al. The effect of curcumin supplementation on weight loss and anthropometric indices: an umbrella review and updated meta-analyses of randomized controlled trials. Am J Clin Nutr. 2023 May;117(5):1005–16. doi: 10.1016/j.ajcnut.2023.03.006. 28 Rains TM et al. Antiobesity
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):1894–900. doi: 10.1038/oby.2008.284. 44 Azad MB et al. Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies. CMAJ. 2017 Jul 17;189(28):E929–39. doi: 10.1503/cmaj.161390. 45 Eweis DS et al. Carbon dioxide
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-claims.html. Accessed 2025 Aug 27. 5 Ibid. 6 Hall KH et al. Ultra-processed diets cause excess calorie intake and weight gain: an inpatient randomized controlled trial of ad libitum food intake. Cell Metab. 2019 Jul 2;30(1):67–77.e3. doi: 10.1016/j.cmet.2019.05.008. 7
Randomistas: How Radical Researchers Changed Our World
by Andrew Leigh · 14 Sep 2018 · 340pp · 94,464 words
Political scientists have created the Experiments in Governance and Politics Network (which lists around 700 studies). Economists have created the American Economic Association’s Randomized Controlled Trials registry (which lists around 1500 studies). Unlike in medicine, most social science journals do not yet refuse to publish unregistered trials, nor
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the Department of Health and Human Services to ‘ensure that States use the funds to support models that have been shown in well-designed randomized controlled trials, to produce sizeable, sustained effects on important child outcomes such as abuse and neglect’. Charitable foundations have a vital role to play
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juvenile delinquency’ (Updated C2 Review), Campbell Collaboration Reviews of Intervention and Policy Evaluations (C2-RIPE), 2002. See also Robert Boruch & Ning Rui, ‘From randomized controlled trials to evidence grading schemes: Current state of evidence-based practice in social sciences’, Journal of Evidence-Based Medicine, vol. 1, no. 1, 2008,
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Deaton & Nancy Cartwright, ‘Understanding and misunderstanding randomized controlled trials’, NBER Working Paper 22595, Cambridge, MA: National Bureau of Economic Research, 2016. 36Gordon C.S. Smith & Jill P. Pell, 2003, ‘Parachute use to prevent death and major trauma related to gravitational challenge: Systematic review of randomised controlled trials’, British Medical Journal, vol. 327
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F.R. Huang, Michelle M. Dowsey, Eric Ee, et al., ‘Coronal alignment correlates with outcome after total knee arthroplasty: Five-year follow-up of a randomized controlled trial’, The Journal of Arthroplasty, vol. 27, no. 9, 2012, pp. 1737–41. 2Sina Babazadeh, Michelle M. Dowsey, James D. Stoney & Peter
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F.M. Choong, ‘Gap balancing sacrifices joint-line maintenance to improve gap symmetry: A randomized controlled trial comparing gap balancing and measured resection’, The Journal of Arthroplasty, vol. 29, no. 5, 2014, pp. 950–4; Michael J. Barrington, David J
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of serum treatment of diphtheria’, British Medical Journal, vol. 317, no. 7167, 1998, pp. 1243. 28Marcia L. Meldrum, ‘A brief history of the randomized controlled trial: From oranges and lemons to the gold standard’, HematologyOoncology Clinics of North America, vol. 14, no. 4, 2000, pp. 745–60. 29Arun Bhatt,
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fruit and vegetables. 53H.C. Bucher, P. Hengstler, C. Schindler & G.Meier, ‘N-3 polyunsaturated fatty acids in coronary heart disease: A meta-analysis of randomized controlled trials’, American Journal of Medicine, vol. 112, no. 4, 2002, pp. 298–304. 54E.C. Rizos, E.E. Ntzani, E. Bika, et al
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, 5 August 2015. 56Stuart A. Armstrong, Eloise S. Till, Stephen R. Maloney & Gregory A. Harris, ‘Compression socks and functional recovery following marathon running: A randomized controlled trial’, The Journal of Strength & Conditioning Research, vol. 29, no. 2, 2015, pp. 528–33. 57Jenna B. Gillen, Brian J. Martin, Martin J.
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–3. 59T. Bakuradze, R. Lang, T. Hofmann, et al., ‘Consumption of a dark roast coffee decreases the level of spontaneous DNA strand breaks: a randomized controlled trial’, European Journal of Nutrition, vol. 54, no. 1, 2015, pp. 149–56. 60Ateev Mehrotra & Allan Prochazka, ‘Improving value in health care—Against
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Robert H. Brook, Caren J. Kamberg, et al., ‘Use of medical care in the RAND Health Insurance Experiment: Diagnosis-and service-specific analyses in a randomized controlled trial’, Medical Care, vol. 24, no. 9, 1986, S1–S87. 16Joseph P. Newhouse, ‘Consumer-directed health plans and the RAND Health Insurance Experiment
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Tobacco in Australia: Facts and issues, Melbourne: Cancer Council Victoria, 2015. 40Kevin G. Volpp, Andrea B. Troxel, Mark V. Pauly, et al., ‘A randomized, controlled trial of financial incentives for smoking cessation’, New England Journal of Medicine, vol. 360, no. 7, 2009, pp. 699–709. 41Center for Disease Control and
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randomized controlled trial in disadvantaged community-based settings’, Journal of consulting and clinical psychology, vol. 80, no. 1, 2012, p. 116. A randomised evaluation of the UK parenting program SureStart also showed positive results: Judy et al., ‘Parenting intervention in Sure Start services for children at risk of developing conduct disorder: Pragmatic randomised controlled
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–56. 19Megan H. Bair-Merritt, Jacky M. Jennings, Rusan Chen, et al., ‘Reducing maternal intimate partner violence after the birth of a child: A randomized controlled trial of the Hawaii Healthy Start Home Visitation Program’, Archives of Pediatrics & Adolescent Medicine, vol. 164, no. 1, 2010, pp. 16–23; Jamila
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van Leerdam, et al., ‘Effect of nurse home visits vs. usual care on reducing intimate partner violence in young high-risk pregnant women: a randomized controlled trial,’ PloS one, vol. 8, no. 10, 2013, e78185. I am grateful to Cathryn Stephens for bringing this research to my attention. 20See
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(9 per cent) produced positive effects, while seventy (91 per cent) produced weak or no positive effects. See Coalition for Evidence-Based Policy, ‘Randomized controlled trials commissioned by the Institute of Education Sciences since 2002: How many found positive versus weak or no effects’, July 2013. 43Robert E. Slavin,
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experiment’, Justice Quarterly, vol. 12, no. 4, 1995, pp. 755–81. 29Anthony A. Braga, ‘Hot spots policing and crime prevention: A systematic review of randomized controlled trials’, Journal of Experimental Criminology, vol. 1, no. 3, 2005, pp. 317–42. 30David L. Weisburd & Lorraine Green, ‘Policing drug hot spots: The
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to over 200 crimes per year. Jerry H. Ratcliffe, Travis Taniguchi, Elizabeth R. Groff & Jennifer D. Wood, ‘The Philadelphia foot patrol experiment: A randomized controlled trial of police patrol effectiveness in violent crime hotspots’, Criminology, vol. 49, no. 3, 2011, pp. 795–831. Thanks to Jerry Ratcliffe for confirming
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of Economic Literature, vol. 55, no. 3, 2017, pp. 866–915. 51Dana Burde & Leigh L. Linden, ‘Bringing education to Afghan girls: A randomized controlled trial of village-based schools’, American Economic Journal: Applied Economics, vol. 5, no. 3, 2013, pp. 27–40. 52The student gains were approximately half a
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also amended to $100,000–$300,000. See Laura and John Arnold Foundation, ‘Laura and John Arnold Foundation announces expanded funding for low-cost randomized controlled trials to drive effective social spending’, press release, 7 December 2015. 9David Halpern, Inside the Nudge Unit: How Small Changes Can Make a
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Trials Project, 2016, www.COMPare-trials.org; Christopher W. Jones, Lukas G. Keil, Wesley C. Holland, et al., ‘Comparison of registered and published outcomes in randomized controlled trials: A systematic review’, BMC Medicine, vol. 13, no. 1, 2015, pp. 1–12; Padhraig S. Fleming, Despina Koletsi, Kerry Dwan & Nikolaos Pandis
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, p. 14. 34Education Endowment Foundation, ‘Classification of the security of findings from EEF evaluations’, 21 May 2014. 35‘David Olds speaks on value of randomized controlled trials’, Children’s Health Policy Centre, Faculty of Health Sciences, Simon Fraser University, 26 May 2014. 36Dean Karlan & Daniel H. Wood, ‘The effect
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major reason why nine tenths of randomised trials commissioned by the US Department of Education reported no positive impact: Coalition for Evidence-Based Policy, ‘Randomized controlled trials commissioned by the Institute of Education Sciences since 2002: How many found positive versus weak or no effects?’, Washington, DC: Coalition for
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7 Alhassan, Lariat 102–3 see also YouWiN! Alm, Steven 97–8 Amazon 7, 131–2, 137, 144, 167 American Economic Association’s Randomized Controlled Trials registry 199 American Psychological Association, and Joseph Jastrow 51 Ames, Phil 184–5 ‘anchoring’ effect 133 Andrade, Leandro 101 Annie Hall 208–9
Science Fictions: How Fraud, Bias, Negligence, and Hype Undermine the Search for Truth
by Stuart Ritchie · 20 Jul 2020
Fraud’, STAT News, 23 June 2017; https://www.statnews.com/2017/06/23/china-death-penalty-research-fraud/ 100. Wang et al., ‘Positive Results in Randomized Controlled Trials on Acupuncture Published in Chinese Journals: A Systematic Literature Review’, The Journal of Alternative and Complementary Medicine 20, no. 5 (May 2014): A129–A129
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–82; https://doi.org/10.1111/j.1365-2362.2009.02240.x. And Candice Estellat, ‘Lack of Head-to-Head Trials and Fair Control Arms: Randomized Controlled Trials of Biologic Treatment for Rheumatoid Arthritis’, Archives of Internal Medicine 172, no. 3 (13 Feb. 2012): pp. 237–44; https://doi.org/10.1001
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Randomised Trial’, BMC Medicine 17, no. 1 (Dec. 2019): 91; https://doi.org/10.1186/s12916-019-1324-7 27. Isabelle Boutron et al., ‘Three Randomized Controlled Trials Evaluating the Impact of “Spin” in Health News Stories Reporting Studies of Pharmacologic Treatments on Patients’/Caregivers’ Interpretation of Treatment Benefit’, BMC Medicine 17
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/page/authors/purpose-scope 60. New England Journal of Medicine: https://www.nejm.org/about-nejm/about-nejm 61. Isabelle Boutron, ‘Reporting and Interpretation of Randomized Controlled Trials with Statistically Nonsignificant Results for Primary Outcomes’, JAMA 303, no. 20 (26 May 2010): pp. 2058–64; https://doi.org/10.1001/jama.2010
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relegation to just an endnote here. Isabelle Boutron et al., ‘Impact of Spin in the Abstracts of Articles Reporting Results of Randomized Controlled Trials in the Field of Cancer: The SPIIN Randomized Controlled Trial’, Journal of Clinical Oncology 32, no. 36 (20 Dec. 2014): pp. 4120–26; https://doi.org/10.1200/JCO.2014
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; https://www.ncbi.nlm. nih.gov/pubmed/13592638 75. Wenjia Hui et al., ‘Fecal Microbiota Transplantation for Treatment of Recurrent C. Difficile Infection: An Updated Randomized Controlled Trial Meta-Analysis’, PLOS ONE 14, no. 1 (2019): e0210016; https://doi.org/10.1371/journal.pone.0210016; Theodore Rokkas et al., ‘A Network Meta
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-Analysis of Randomized Controlled Trials Exploring the Role of Fecal Microbiota Transplantation in Recurrent Clostridium Difficile Infection’, United European Gastroenterology Journal 7, no. 8 (Oct. 2019): pp. 1051–63
Fixed: Why Personal Finance is Broken and How to Make it Work for Everyone
by John Y. Campbell and Tarun Ramadorai · 25 Jul 2025
and certainly have a role in policy, have their limits. To begin with, the benefits of nudges have been somewhat oversold. A metastudy of 126 randomized control trials covering 23 million individuals shows that nudges have roughly a quarter of the effect in the field as the outcomes reported in academic studies
I Think You'll Find It's a Bit More Complicated Than That
by Ben Goldacre · 22 Oct 2014 · 467pp · 116,094 words
the Lancet paper to which they refer. Antiretroviral medications have repeatedly been shown to save lives in systematic reviews of large numbers of well-conducted randomised controlled trials. The Lancet paper they reference simply surveys the first decade of patients who received highly active antiretroviral therapy (HAART) – modern combinations of multiple antiretroviral
Engineering Security
by Peter Gutmann
and Charlotte Ringsted, Medical Education, Vol.43, No.1 (January 2009), p.5. [614] “Repeated testing improves long-term retention relative to repeated study: a randomised controlled trial”, Douglas Larsen, Andrew Butler and Henry Roediger III, Medical Education, Vol.43, No.12 (December 2009), p.1174. [615] “Why Testing Improves Memory: Mediator
Everything Is Tuberculosis: The History and Persistence of Our Deadliest Infection
by John Green · 18 Mar 2025 · 158pp · 49,742 words
it’s certainly an improvement on what came before, because before DOTS there was no comprehensive global strategy for addressing TB in poor countries. But randomized control trials have found that directly observed therapy is no more effective than giving patients their pills to take home in two-week or monthlong cycles
Blank Space: A Cultural History of the Twenty-First Century
by W. David Marx · 18 Nov 2025 · 642pp · 142,332 words
. Holroyd-Leduc, Marc J. Poulin, and David B. Hogan, “Effect of Nutrients, Dietary Supplements and Vitamins on Cognition: A Systematic Review and Meta-Analysis of Randomized Controlled Trials,” Canadian Geriatrics Journal 18, no. 4 (2015): 231–45, https://doi.org/10.5770/cgj.18.189; Julia Belluz, “How Dietary Supplements Evade Regulation
Bad Science
by Ben Goldacre · 1 Jan 2008 · 322pp · 107,576 words
you ever be lucky enough to read them, play this classic drug-company card very assertively. They will claim, for example, that a ‘placebo-controlled randomised control trial’ has shown benefits from a particular vitamin, when what they mean is, it showed changes in a ‘surrogate outcome’. For example, the trial may
Inside the Nudge Unit: How Small Changes Can Make a Big Difference
by David Halpern · 26 Aug 2015 · 387pp · 120,155 words
, 45: 487–498. Ni Mhurchu, C., Blakely, T., Jiang, Y., et al. (2010), ‘Effects of price discounts and tailored nutrition education on supermarket purchases: a randomized controlled trial’, Am J Clin Nutr, 91: 736–747. 3 See EAST for a summary of these results in more detail. We also tested adding both
Food Allergy: Adverse Reactions to Foods and Food Additives
by Dean D. Metcalfe · 15 Dec 2008 · 623pp · 448,848 words
How to Read a Paper: The Basics of Evidence-Based Medicine
by Trisha Greenhalgh · 18 Nov 2010 · 321pp · 97,661 words
Bad Pharma: How Medicine Is Broken, and How We Can Fix It
by Ben Goldacre · 1 Jan 2012 · 402pp · 129,876 words
The Diet Myth: The Real Science Behind What We Eat
by Tim Spector · 13 May 2015 · 382pp · 115,172 words
The End of My Addiction
by Olivier Ameisen · 23 Dec 2008 · 312pp · 89,728 words
Sickening: How Big Pharma Broke American Health Care and How We Can Repair It
by John Abramson · 15 Dec 2022 · 362pp · 97,473 words
Radical Uncertainty: Decision-Making for an Unknowable Future
by Mervyn King and John Kay · 5 Mar 2020 · 807pp · 154,435 words
The Rise and Fall of Modern Medicine
by M. D. James le Fanu M. D. · 1 Jan 1999 · 564pp · 163,106 words
Jellyfish Age Backwards: Nature's Secrets to Longevity
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The Emperor of All Maladies: A Biography of Cancer
by Siddhartha Mukherjee · 16 Nov 2010 · 1,294pp · 210,361 words
Unhealthy societies: the afflictions of inequality
by Richard G. Wilkinson · 19 Nov 1996 · 268pp · 89,761 words
Gene Eating: The Science of Obesity and the Truth About Dieting
by Giles Yeo · 3 Jun 2019 · 351pp · 112,079 words
Cogs and Monsters: What Economics Is, and What It Should Be
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The Big Fat Surprise: Why Butter, Meat and Cheese Belong in a Healthy Diet
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How to Read Numbers: A Guide to Statistics in the News (And Knowing When to Trust Them)
by Tom Chivers and David Chivers · 18 Mar 2021 · 172pp · 51,837 words
Practical Manual of Thyroid and Parathyroid Disease
by Asit Arora, Neil Tolley and R. Michael Tuttle · 2 Jan 2009 · 228pp · 119,593 words
Sleepyhead: Narcolepsy, Neuroscience and the Search for a Good Night
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The Cancer Chronicles: Unlocking Medicine's Deepest Mystery
by George Johnson · 26 Aug 2013 · 465pp · 103,303 words
The Unpersuadables: Adventures With the Enemies of Science
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The Patient Will See You Now: The Future of Medicine Is in Your Hands
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Vaxxers: The Inside Story of the Oxford AstraZeneca Vaccine and the Race Against the Virus
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Overdosed America: The Broken Promise of American Medicine
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The Art of Statistics: How to Learn From Data
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The Nocturnal Brain: Nightmares, Neuroscience, and the Secret World of Sleep
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Ageless: The New Science of Getting Older Without Getting Old
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Emotional Ignorance: Lost and Found in the Science of Emotion
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Jaws
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The End of Pain: How Nutrition and Diet Can Fight Chronic Inflammatory Disease
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The Norm Chronicles
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Misbehaving: The Making of Behavioral Economics
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Good Times, Bad Times: The Welfare Myth of Them and Us
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Covid by Numbers
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Enlightenment Now: The Case for Reason, Science, Humanism, and Progress
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Scarcity: The True Cost of Not Having Enough
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Imaginable: How to See the Future Coming and Feel Ready for Anything―Even Things That Seem Impossible Today
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Conflicted: How Productive Disagreements Lead to Better Outcomes
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Black Box Thinking: Why Most People Never Learn From Their Mistakes--But Some Do
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The Pot Book: A Complete Guide to Cannabis
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The Organized Mind: Thinking Straight in the Age of Information Overload
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Uncontrolled Spread: Why COVID-19 Crushed Us and How We Can Defeat the Next Pandemic
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The Checklist Manifesto: How to Get Things Right
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Human Frontiers: The Future of Big Ideas in an Age of Small Thinking
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Growth: A Reckoning
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The Matter of the Heart: A History of the Heart in Eleven Operations
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