by Jeanne Lenzer · 12 Dec 2017 · 328pp · 98,127 words
epilepsy because it helps patients control their seizures—a necessary claim in light of the $40,000 price tag. But Barkan says, “There was a systematic bias in what [the] Cyberonics folks did.” When all the data were in, Cyberonics wanted to exclude a particular VNS patient from analysis as an “outlier
by David Spiegelhalter · 14 Oct 2019 · 442pp · 94,734 words
evidence is actually worth. For example, intensive analysis of data sets derived from routine data can increase the possibility of false discoveries, both due to systematic bias inherent in the data sources and from carrying out many analyses and only reporting whatever looks most interesting, a practice sometimes known as ‘data-dredging
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occasion, and so being a precise or repeatable number. Valid, in the sense of measuring what you really want to measure, and not having a systematic bias. Figure 3.1 Process of inductive inference: each arrow can be interpreted as ‘tells us something about’1 For example, the adequacy of the sex
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we hadn’t done X?’). We are a long way from AI having this ability. This book emphasizes the classic statistical problems of small samples, systematic bias (in the statistical sense) and lack of generalizability to new situations. The list of challenges for algorithms shows that although having masses of data may
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is conditional not only on the truth of the null hypothesis, but also on all other assumptions underlying the statistical model, such as lack of systematic bias, independent observations, and so on. This whole process has become known as Null Hypothesis Significance Testing (NHST) and, as we shall see below, it has
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with a control group. What is the statistical uncertainty / confidence in the findings? Check margins of error, confidence intervals, statistical significance, sample size, multiple comparisons, systematic bias. Is the summary appropriate? Check appropriate use of averages, variability, relative and absolute risks. HOW TRUSTWORTHY IS THE SOURCE? How reliable is the source of
by Tim Harford · 2 Feb 2021 · 428pp · 103,544 words
, 149, 151, 154 and Google Flu Trends, 153–57 vs. human judgment, 167–71 pattern-recognizing, 183 and proliferation of big data, 157–59 and systematic bias, 166 and teacher evaluations, 163–64 trustworthiness of, 179–82 See also big data Allegory of Faith, The (Vermeer), 29–30 Allied Art Commission, 21
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criminal justice, 176–79 in sampling, 135–38, 142–45, 147–51 selection bias, 2, 245–46 survivorship bias, 109–10, 112–13, 122–26 systematic bias in algorithms, 166 and value of statistical knowledge, 17 big data and certification of researchers, 182 and criminal justice, 176–79 and excessive credulity in
by Sebastien Page · 4 Nov 2020 · 367pp · 97,136 words
bps—a fraction of our 300 bps of precost alpha. We left it to the reader to interpret whether this slight excess beta constitutes a systematic bias, but if so, the impact remains small relative to the magnitude of the net alphas. Regarding liquidity, our outsiders have a similar liquidity profile, on
by Ben Goldacre · 1 Jan 2012 · 402pp · 129,876 words
you’d expect to see, over time, in any trial. Such rules are useful because they restrict the intrusion of human judgement, which can introduce systematic bias. But whatever we do about early stopping in medicine, it will probably pollute the data. A review from 2010 took around a hundred truncated trials
by Sarah Boslaugh · 10 Nov 2012
expect random error to affect an individual’s score consistently in one direction or the other. Random error makes measurement less precise but does not systematically bias results because it can be expected to have a positive effect on one occasion and a negative effect on another, thus canceling itself out over
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diameter one µm (micrometer), any bacteria smaller than this will not be part of the population that you are observing. This sampling limitation will introduce systematic bias into the study; however, as long as you are clear that the population about which you can make inferences is bacteria of diameter greater than
by Trisha Greenhalgh · 18 Nov 2010 · 321pp · 97,661 words
ethical considerations References Chapter 4: Assessing methodological quality Was the study original? Whom is the study about? Was the design of the study sensible? Was systematic bias avoided or minimised? Was assessment ‘blind’? Were preliminary statistical questions addressed? Summing up References Chapter 5: Statistics for the non-statistician How can non-statisticians
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?’). 6. The sample size was too small (see section ‘Were preliminary statistical questions addressed?’). 7. The study was uncontrolled or inadequately controlled (see section ‘Was systematic bias avoided or minimised?’). 8. The statistical analysis was incorrect or inappropriate (see Chapter 5). 9. The authors have drawn unjustified conclusions from their data. 10
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benefit of brown rice over white rice in the treatment of beriberi [8].) The problems of non-random allocation are discussed further in section ‘Was systematic bias avoided or minimised?’ in relation to determining whether the two groups in a trial can reasonably be compared with one another on a statistical level
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section ‘Three preliminary questions to get your bearings’). 4. Potentially eradicates bias by comparing two otherwise identical groups (but see subsequent text and section ‘Was systematic bias avoided or minimised?’). 5. Allows for meta-analysis (combining the numerical results of several similar trials) at a later date; see section ‘Ten questions to
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case–control study is the precise definition of who counts as a ‘case’, because one misallocated individual may substantially influence the results (see section ‘Was systematic bias avoided or minimised?’). In addition, such a design cannot demonstrate causality—in other words, the association of A with B in a case–control study
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. Does the prone sleeping position increase the risk of cot death (sudden infant death syndrome)? Does whooping cough vaccine cause brain damage? (see section ‘Was systematic bias avoided or minimised?’). Do overhead power cables cause leukaemia? Cross-sectional surveys We have probably all been asked to take part in a survey, even
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(because you can't fault the methods at all). These five questions—was the study original, whom is it about, was it well designed, was systematic bias avoided (i.e. was the study adequately ‘controlled’) and was it large enough and continued for long enough to make the results credible—are considered
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) in recent years is the emerging science of patient-reported outcomes measures, which I cover in the section ‘PROMs’ on page 223. Was systematic bias avoided or minimised? Systematic bias is defined by epidemiologists as anything that erroneously influences the conclusions about groups and distorts comparisons [4]. Whether the design of a study is
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of times by the same assessors, using the same outcome measures [5] [6]. Different study designs call for different steps to reduce systematic bias. Randomised controlled trials In an RCT, systematic bias is (in theory) avoided by selecting a sample of participants from a particular population and allocating them randomly to the different groups
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this ruling has subsequently been challenged, the principle stands—that assignment of ‘caseness’ in a case–control study must be performed rigorously and objectively if systematic bias is to be avoided. Was assessment ‘blind’? Even the most rigorous attempt to achieve a comparable control group will be wasted effort if the people
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terms of its: methodological quality—that is, extent to which the design and conduct are likely to have prevented systematic errors (bias) (see section ‘Was systematic bias avoided or minimised?’); precision—that is, a measure of the likelihood of random errors (usually depicted as the width of the confidence interval around the
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plot bluffing, deliberate boundaries fuzzy organisational break-even point browsing, informal Caesarean section, see induced delivery CardioSource care, quality of care pathways, integrated (critical) case systematic bias case reports case studies ‘caseness’ causation tests for CBT (cognitive behaviour therapy) Centre for Evidence-Based Medicine (CEBM) CHAIN (Contact, Help, Advice and Information Network
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controlled RCT, see randomised controlled trials CME (continuing medical education) Cochrane, Archie Cochrane Collaboration Cochrane EPOC, see EPOC group cognitive behaviour therapy (CBT) cohort studies systematic bias collection of data collective knowledge common sense comparable groups COMPASEN format completeness of follow-up complex interventions complexity theory confidence intervals diagnostic tests conflict of
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statistical QUORUM statement quota sampling frame r-value random samples, questionnaire research randomised controlled trials (RCTs) checklist CONSORT statement cumulative meta-analyses hierarchy of evidence systematic bias rating scale measurements reading papers ‘real-life’ circumstances receptive context for change recruitment dates, CONSORT checklist reflexivity regression (statistical) rejection, papers relevant non-significant results
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withdrawal of patients subgroups, complex interventions retrospective analysis subjective judgements subpopulations surfactant treatment surrogate endpoints surveys cross-sectional literature longitudinal Swinglehurst, Deborah synopses synthesised sources systematic bias systematic reviews databases evaluation evidence-based practice systematically skewed samples t-test table, two-by-two tails target population target variable X2-test tests diagnostic
by Norman Finkelstein · 9 Jan 2018 · 578pp · 170,758 words
up a legal whitewash. • • • It cannot be seriously doubted that Amnesty International’s reports on Operation Protective Edge lacked objectivity and professionalism. They betrayed a systematic bias against Hamas and in favor of Israel. They also registered a steep regression from the exacting standard Amnesty set in its reports spanning the past
by Igor Tulchinsky · 30 Sep 2019 · 321pp
categories. We conclude with some practical suggestions for quantitative practitioners and firms. CATEGORIES OF BIAS We broadly categorize bias as systematic or behavioral. Investors introduce systematic bias by inadvertently coding it into their quantitative processes. By contrast, investors introduce behavioral bias by making ad hoc decisions rooted in their own human behavior
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. Over a period of time, both systematic and behavioral bias yield suboptimal investment outcomes. SYSTEMATIC BIASES There are two important sources of systematic bias: look-ahead bias and data mining. Finding Alphas: A Quantitative Approach to Building Trading Strategies, Second Edition. Edited by Igor Tulchinsky et al. and WorldQuant
by Daniel Kahneman · 24 Oct 2011 · 654pp · 191,864 words
common basis. On the other hand, the errors that individuals make are independent of the errors made by others, and (in the absence of a systematic bias) they tend to average to zero. However, the magic of error reduction works well only when the observations are independent and their errors uncorrelated. If
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